Probability of significant regression in LV mass as a function of weight loss. The probability of a significant regression (defined as ≥10% decrease) in height-indexed LV mass increases with greater degrees of weight loss. Data from all participants was grouped into twenty quantiles according to percent body weight change between Exam 1 and 5. The proportion of individuals in each quantile experiencing a 10% or greater reduction in height-indexed LV mass is plotted versus the mean percentage body weight change for that quantile. The underlying data were fit to a logistic model.