Skip to main content
  • Poster presentation
  • Open access
  • Published:

Pulse wave velocity does not predict ventricular strain in Ross patients


Worsened aortic pathology may adversely affect ventricular function over time. Patients requiring the Ross procedure are at risk for aortopathy including worsened aortic stiffness, and are at risk for left ventricular (LV) dysfunction. Early changes in vascular stiffness can be measured with cardiovascular magnetic resonance imaging (CMR) by pulse wave velocity (PWV). Likewise, decreased LV strain may precede changes in ejection fraction. We hypothesized thoracic aorta PWV would predict impaired left ventricular systolic function in patients after the Ross procedure.


Ross patients studied by CMR from 2007-2013 at the University of Michigan Health System were reviewed. Exclusion criteria included CMR under sedation/anesthesia, neoaortic valve replacement, or inadequate CMR data. PWV was calculated with the aortic arch distance between ascending and descending aorta on phase contrast images and the time between the pulse wave feet at those sites. Peak LV circumferential strain was measured using feature tracking software (TomTec, Unterschleissheim, Germany). Correlation of PWV and LV systolic strain with LV systolic parameters and other variables was examined via Pearson and Spearman correlation coefficients, two-sided t-test, analysis of variance and Wilcoxon rank sum test where appropriate.


31 patients were included, with median age at CMR of 28.1 years (range 15.4-61.9) and mean time from Ross procedure of 11.5 ± 3.9 years. Worsened PWV was associated with prior root replacement (7.2 m/s(5.4-8.7) vs. 4.0 m/s(2.7-5.1), p = 0.05) and aortic insufficiency (r = 0.47, p = 0.01), and correlated with aortic dilatation at the sinotubular junction (r = 0.53, p = 0.01) and the ascending aorta (r = 0.49, p = 0.01), excluding patients with root replacement. LV circumferential strain was associated with measures of LV systolic function: ejection fraction (r = -0.77, p = < .0001), end diastolic volume (r = 0.62, p = 0.0002), end systolic volume (r = 0.73, p = < .0001) and mass (r = 0.62, p = 0.0002). It was also associated with systemic hypertension (-19.1 ± 2.9 vs. -24.1 ± 3.7, p = 0.01) and pre-Ross diagnosis of aortic insufficiency versus aortic stenosis (-20.7 ± 4.4 vs. -27.0 ± 3.8, p = 0.03). There was no correlation between PWV and measurements of LV systolic performance, including strain (r = 0.09, p = 0.61), ejection fraction (r = 0.12, p = 0.52) or end systolic volume (r = 0.13, p = 0.50).


Patients following Ross procedure have increased aortic stiffness associated with aortic root dilatation and history of aortic root replacement subsequent to their Ross operation. While systemic hypertension and pre-operative diagnosis of aortic insufficiency were correlated with worsened LV circumferential strain, this study could not detect a relationship between aortic stiffness and global measures of LV systolic function.



Author information

Authors and Affiliations


Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Cite this article

Christensen, J., Lu, J.C., Yu, S. et al. Pulse wave velocity does not predict ventricular strain in Ross patients. J Cardiovasc Magn Reson 16 (Suppl 1), P113 (2014).

Download citation

  • Published:

  • DOI: