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Aortic 4D flow: quantifying the effects of contrast and field strength at 1.5 T, 3T and 7T
Journal of Cardiovascular Magnetic Resonancevolume 16, Article number: P169 (2014)
4D flow is a promising new method for assessment of aortic pathology, but is limited by signal-to-noise ratio (SNR) leading to long acquisition times. Higher field strength may prove a solution. SNR in aortic 4D flow increases at 3T versus 1.5T (Strecker et al, JMRI 2012) and further by adding a contrast agent (Bock et al, MRM 2010). This work extends this comparison to human 7 Tesla and quantifies the field strength dependent effects of contrast agents.
Four healthy male volunteers were scanned six times: both with and without contrast (MultiHance, Braco, Milano, Italy) at each field 1.5 T, 3 T, and 7 T. All scans were acquired within four weeks and on Siemens scanners. Identical protocols were used, TR/TE 4.33/2.5 ms, temporal resolution 52 ms, bandwidth 1502 Hz/pixel, matrix 192 × 124 × 24, field of view 384 × 310 × 60 mm3, resolution 2.0 × 2.5 × 2.5 mm3, flip angle 7°, segmentation 3, GRAPPA 2, VENC 150 cm/s. At 7 T no RF spoiling was employed and a flip angle post B1 shimming ranging from 5° to 7° through the aorta. 7 T scans employed dynamic B1 shimming alternating between navigator and aorta specific shim. SNR was calculated by taking the difference of two symmetrically flow-encoded in one direction magnitude images (enc1 and enc3). SNR(r) = mean(enc1(r, t) + enc3(r, t))/√2 (std(enc1(r, t) - enc3(r, t))), r is the spatial coordinate and t are the temporal frames during diastole. SNR was assessed in the descending aorta over a 40 × 7.5 mm2 × aorta diameter ROI centered 60 mm below the midpoint of the aortic arch.
SNR for each of the six scans for each subject are plotted and a set of stream lines seeded in the LV (7 T data) are shown. The mean ± SD increase in SNR due to contrast agent is 1.8 ± 0.2, 1.8 ± 0.5 and 1.4 ± 0.2 for 1.5 T, 3 T and 7 T respectively. The mean ± SD increase in SNR due to field strength without and with the contrast agent is 1.8 ± 0.4 and 1.7 ± 0.1 for 1.5 T to 3 T and 2.1 ± 0.7 and 1.7 ± 0.4 for 3 T to 7 T. The average difference in peak net flow rate at the same location in descending aorta at 7 T compared to 3 T was 7 ± 7 ml/s. Of interest is that increases in SNR by stepping up in field strength are comparable to the increase from contrast.
4D aortic flow is feasible at 7 Tesla and yields substantial SNR improvements over lower field strengths. Future work will exploit this higher SNR to explore improved spatial and/or temporal resolution.
Medical Research Council (UK) and British Heart Foundation.