Skip to content

Advertisement

  • Poster presentation
  • Open Access

Quantitative non-contrast T1 mapping of left ventricle in children and young adults

  • 1,
  • 1,
  • 1,
  • 1 and
  • 1
Journal of Cardiovascular Magnetic Resonance201416 (Suppl 1) :P268

https://doi.org/10.1186/1532-429X-16-S1-P268

  • Published:

Keywords

  • Cardiac Magnetic Resonance
  • Short Axis
  • Cardiac Dysfunction
  • Hypertrophic Cardiomyopathy
  • Myocardial Fibrosis

Background

Quantification of myocardial T1 values is a promising tool that may be used to quantify myocardial fibrosis. The purpose of our study is to establish a preliminary reference value of normal left ventricular (LV) myocardium in children and young adults using non-contrast T1 mapping.

Methods

The HIPAA compliant prospective study was IRB approved. Sixteen patients (mean age 15.4 years; range 5-25 years) underwent cardiac magnetic resonance (CMR) (1.5-T) including non-contrast short axis T1 mapping (modified Look-Locker [MOLLI] sequence). Twelve patients with no intrinsic myocardial abnormality based on clinical history, standard biomarkers and echocardiographic criteria were compared with 3 patients having cardiac dysfunction and 1 patient with hypertrophic cardiomyopathy (HCM). Short axis images were manually contoured to outline the epicardium and endocardium using AHA 16-segment model yielding 192 normal myocardial segments, 48 segments in patients with cardiac dysfunction, and 16 segments in a patient with HCM. Patient groups were compared using one-way analysis of co-variance (ANOVA). Chi-squared test was performed to compare appropriateness of discrete data. Receiver operating characteristic (ROC) curve was used to obtain a cut-off value of T1 relaxation time. Statistical significance was defined as p < 0.05.

Results

Myocardial T1 values in the normals (982.1 ± 30.0 ms) were significantly different (p < 0.001) when compared to patients with cardiac dysfunction (1021.0 ± 34.8 ms) and hypertrophic cardiomyopathy (1039.7 ± 20.8 ms). Non-contrast myocardial T1 cutoff of 1005 ms conceded a sensitivity of 80% and specificity of 83% when compared to patients with cardiomyopathy (p < 0.001).

Conclusions

The normal non-contrast T1 values of LV myocardium in children and young adults obtained can be used as a baseline for comparison to patients with underlying myocardial abnormalities. Enrollment is underway to validate our results in a larger cohort.

Funding

None.
Figure 1
Figure 1

Non-contrast myocardial T1 values in normal and cardiomyopathy (non-hypertrophic and hypertrophic) patients in children and young adults. Mean values of left ventricular myocardium using non-contrast T1 MOLLI in normal population is 982.1 ± 30.0 ms. Non-hypertrophic cardiomyopathy (CM) and hypertrophic cardiomyopathy (HCM) has mean values of 1021.0 ± 34.8 ms and 1039.7 ± 20.8 ms. Values between these three groups were significantly different with p < 0.001.

Figure 2
Figure 2

Receiver-operating characteristic (ROC) curve to determine threshold value of T1 relaxation time of left ventricular myocardium. Threshold of non-contrast T1 value to differentiate normal patients from patients with cardiomyopathy was calculated using ROC curve. Cut-off value of 1005 ms yielded sensitivity of 80% and specificity of 83% with area under curve (AUC) of 0.84 ± 0.03 (p < 0.001).

Authors’ Affiliations

(1)
Northwestern University, Chicago, Illinois, USA

Copyright

© Parekh et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

Advertisement