Volume 16 Supplement 1

Abstracts of the 17th Annual SCMR Scientific Sessions

Open Access

Extent of late gadolinium enhancement in patients with hypertrophic cardiomyopathy in correlation with serum MMP9 as an indicator of myocardial fibrosis

  • Maxim Avanesov1,
  • Monica Patten2,
  • Julia Münch2,
  • Dennis Säring3,
  • Peter Bannas1,
  • Enver Tahir1,
  • Gerhard Adam1 and
  • Gunnar Lund1
Journal of Cardiovascular Magnetic Resonance201416(Suppl 1):P291

https://doi.org/10.1186/1532-429X-16-S1-P291

Published: 16 January 2014

Background

Myocardial fibrosis is known to be associated with abnormal cardiac remodeling and a poorer prognosis in patients with hypertrophic cardiomyopathy. Our purpose was to compare the size of late gadolinium enhancement (LGE) obtained by cardiac magnetic resonance (CMR) imaging in patients with hypertrophic cardiomyopathy (HCM) with serum MMP9, which is a marker of myocardial fibrosis.

Methods

CMR was performed in 50 patients with HCM (mean age: 54.9 ± 14.1 years, 27 women) using a 1.5 Tesla scanner (Achieva, Philips). Size of fibrosis was quantified in percent of total myocardium on inversion-recovery images after injection of 0,2 ml/kg gadolinium using the HeAT software and compared with levels of serum MMP9. A serum level of > 46 ng/ml was regarded as increased.

Results

Nine out of 50 patients with HCM (18 %) showed no fibrosis on LGE-CMR. In the remaining 41 patients, mean size of fibrosis was 13,3 ± 10,3% on LGE-CMR. In all patients, the mean MMP9 level was 54,4 ± 35,2 ng/ml. Size of fibrosis on LGE-CMR strongly correlated with MMP9 levels (R2 = 0,557, Pearson's r = 0,75, p < 0,01). In the 9 patients with no LGE, MMP9 was with 29,6 ± 14,2 ng/ml significantly lower compared to the 41 patients with LGE and levels of 59,8 ± 36,2 ng/ml (p = 0,01).

Conclusions

Size of fibrosis on LGE-CMR strongly correlated with the serum fibrosis marker MMP9 in patients with HCM. There were no patients with increased fibrosis on LGE-CMR and normal MMP9, so that an increased MMP9 makes a myocardial fibroses observed by LGE-CMR probable. However, 2% of patients revealed no LGE despite increased MMP9 levels. These patients may have a diffuse myocardial fibrosis which is not detectable by standard LGE-CMR.

Funding

No Funding has been paid during the study.
Figure 1

Correlation between LGE and MMP 9values (Pearson's r = 0,75, p < 0,01).

Authors’ Affiliations

(1)
Center for Radiology and Endoscopy, Diagnostic and Interventional Radiology
(2)
University Heart Center, General and Interventional Cardiology
(3)
Center for Experimental Medicine, Computational Neuroscience

Copyright

© Avanesov et al.; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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