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Myocardial strain imaging with radial acquisitions (SIRA) reduces tag fading compared to Cartesian sampling


Myocardial tagging is considered a gold-standard technique to derive myocardial strain using cardiac magnetic resonance (CMR) in large epidemiologic studies. Nevertheless technical limitations related to tag line fading (via T1 relaxation) limit generalizability and reproducibility of this technique. Our purpose was to test myocardial tagging with radial k-space acquisition against routinely utilized Cartesian k-space sampling techniques, in order to potentially minimize tag-line fading over the cardiac cycle.


We compared a new tagging sequence with radial acquisitions for cardiac MRI to a routinely-utilized clinical tagging sequence with Cartesian sampling. Both sequences were added pre-contrast to routine clinical scans of 14 patients. The per phase change in grayscale contrast due to T1 relaxation ("tag fading") of tagged myocardium was modeled using a non-linear fit with maximum likelihood estimation to an exponential decay curve and compared between groups. Peak Eulerian circumferential strain (Ecc) was compared using HARP software.


14 patients (mean age 54 ± 16 years and 36% were men) and mean left ventricular ejection fraction 53 ± 16% (LVEF) were included. Tag fading differed significantly between radial and Cartesian sampling; the exponential decay coefficient was -0.045 ± 0.011 for the Cartesian and significantly higher than the-decay coefficient value of 0.029 ± 0.007 for radial read-outs (p < 0.001). Due to less tag fading myocardial strain could be evaluated for more segments acquired with radial, compared to Cartesian read-outs (p < 0.001). The intra-observer reliability for Ecc was higher for radial (r = 0.99, p < 0.001) than Cartesian (r = 0.86, p=<0.001) images (p = 0.002 for comparison). The bias was 0.9% and limits of agreement -4.1 to 6.0% with concordance = 0.86 (p < 0.001) for Ecc-radial versus Ecc-Cartesian. Both tagging methods correlated with LVEF, r = -0.86 (p < 0.001) for Ecc-radial versus r = -0.83 (p < 0.001) for Ecc-Cartesian.


Radial k-space acquisition with very low flip-angle excitations leads to better reliability for myocardial strain relative to standard, widely employed Cartesian readouts, while maintaining good signal-to-noise. Radial k-space acquisition is a promising new approach for evaluating myocardial strains using MRI.



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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Hulten, E., Shah, R.V., Abbasi, S. et al. Myocardial strain imaging with radial acquisitions (SIRA) reduces tag fading compared to Cartesian sampling. J Cardiovasc Magn Reson 16 (Suppl 1), P35 (2014).

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