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Predicting mortality in patients with non-ischemic dilative cardiomyopathy: Potential of extracellular volume imaging by cardiovascular magnetic resonance
Journal of Cardiovascular Magnetic Resonance volume 16, Article number: P88 (2014)
Background
Predicting mortality in patients with non-ischemic dilated cardiomyopathy (NIDCM) is currently demanding and requires complex models. Assessing the extracellular volume fraction (ECV) by T1-mapping cardiovascular magnetic resonance (CMR) is an attractive approach to quantify myocardial injury as a potential predictor of adverse events in these patients. This study evaluated ECV imaging by T1-mapping CMR in comparison with the established "Seattle Heart Failure Model" (SHFM; http://www.seattleheartfailuremodel.org).
Methods
This study included 50 patients with heart failure and reduced left ventricular (LV) ejection fraction due to non-ischemic cardiomyopathy. The SHFM was used to estimate 1, 2 and 5 year mortalities as well as life expectancy, respectively. T1 quantification was performed at 1.5 Tesla using the modified Look-Locker inversion-recovery (MOLLI) sequence on 3 short-axes before and 15 minutes after administration of 0.075 mmol/kg gadolinium-BOPTA. Global myocardial ECV was then calculated from native and post-contrast T1 maps generated by a dedicated plug-in written for the OsiriX software, respectively.
Results
Median predicted 1-, 2- and 5-year mortalities were 4% (interquartile range 2-6%), 7% (interquartile range 5-12%) and 16% (interquartile range 12-28%) in the study population, respectively. Median estimated life expectancy was 13 years (interquartile range 9-15 years). A significant correlation was found between global myocardial ECV and predicted 1- (r = 0.47; p < 0.001), 2- (r = 0.46; p < 0.001) and 5-year mortality (r = 0.46; p < 0.001), respectively. Furthermore, a significant inverse correlation was found between global myocardial ECV and predicted life expectancy (r = -0.37; p < 0.01).
Conclusions
Myocardial injury as quantified by ECV-imaging correlates well with predicted mortality and has great potential to improve risk stratification in patients with heart failure due to NIDCM.
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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
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Koopmann, K., Radunski, U.K., Bohnen, S. et al. Predicting mortality in patients with non-ischemic dilative cardiomyopathy: Potential of extracellular volume imaging by cardiovascular magnetic resonance. J Cardiovasc Magn Reson 16 (Suppl 1), P88 (2014). https://doi.org/10.1186/1532-429X-16-S1-P88
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DOI: https://doi.org/10.1186/1532-429X-16-S1-P88