Representative CAD patient study with high-grade RCA stenosis. (a): End-systolic frames (peak myocardial enhancement phase) corresponding to the proposed real-time cine first-pass perfusion method at the apical, mid, and basal ventricular levels. (b): standard SSFP cine scan (end-systolic frames) in the same 3 slices performed at baseline (resting state) prior to adenosine infusion. (c): invasive coronary angiogram. The observed stress perfusion defects (yellow arrows) are consistent with the angiogram in (c), which shows a high-grade stenosis (≈90%) in proximal RCA (dominant vessel) and ≈70% stenosis in mid LAD. For the mid slice, the perfusion defect territory (inferior wall) shows WMA in comparison to the baseline end-systolic frame, i.e., a larger end-systolic LV cavity area is seen in (a2) compared to (b2). This is consistent with the angiographically documented high-grade RCA stenosis.