- Oral presentation
- Open Access
Whole-heart contrast enhanced coronary magnetic resonance angiography using respiratory image based navigation in patients with congenital heart disease
© Vieira et al; licensee BioMed Central Ltd. 2015
- Published: 3 February 2015
- Coronary Imaging
- Gadobenate Dimeglumine
- Vessel Length
- Coronary Magnetic Resonance Angiography
- Vessel Sharpness
Despite ongoing advances in magnetic resonance (MR) sequence development, coronary imaging in paediatric patients remains challenging. MR imaging of the coronary arteries can be difficult due to high heart rates (HR), small diameter of the coronary arteries, and poor contrast between the blood pool and extravascular structures. The use of higher relaxivity contrast agents has been shown to improve coronary imaging in adult patients significantly, but no data is available in paediatric patients.
Children over 2 years-old with a clinically indicated MR study, were prospectively enrolled between September 2013 and August 2014.
Patients were imaged under general anaesthesia with an ECG-triggered, free breathing whole-heart 3D balanced steady-state free precession (bSSFP) sequence, using a respiratory image based navigator tracking the heart motion and a T2 preparation prepulse (sequence A). Gadobenate dimeglumine (0.2mL per kilogram of body weight) was then administered as a single bolus for a time-resolved 3D MR angiography. Five minutes after contrast administration, a single-shot Look-Locker pulse sequence was acquired to determine the optimal inversion time to null the myocardium. Sequence B was adapted to the reduced T1 relaxation time of the blood pool, including an inversion prepulse to null signal from myocardium. Coronary reformatting and quantitative analysis of vessel length, diameter and sharpness was performed using dedicated software ("Soap-Bubble").
Twenty-nine consecutive paediatric patients were included (21 male; 8 female; mean age=5.28 ± 3.4 years). There was no significant difference in the HR during both sequences acquisitions (mean HR of 78 ± 14.3bpm sequence A vs 78 ± 14.4bpm sequence B; p=0.698). Mean vessel length was 4.59 ± 2.51mm (A) vs 4.52 ± 2.69mm (B) (p=0.78) for a mean vessel diameter (first 4cm) of 2.14 ± 0.38mm (A) vs 2.08 ± 0.42mm (B) (p=0.091). The use of an inversion recovery bSSFP 3D sequence with gadobenate dimeglumine resulted in improved SNR (p<0.005), CNR (p=0.005), and vessel wall sharpness (p<0.005). There was no correlation between HR during acquisition and vessel sharpness (p=0.335).
The use of gadobenate dimeglumine with a specific sequence design results in improved coronary imaging quality even in small children with high HR. This may allow to replace invasive cardiac catheterization for diagnostic coronary imaging and preoperative planning in these patients.
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