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Evidence of non-transferrin-bound iron in patients with ST-elevation myocardial infarction: relationship with microvascular obstruction and post-reperfusion myocardial hemorrhage
Journal of Cardiovascular Magnetic Resonance volume 17, Article number: P118 (2015)
Hereditary hemochromatosis, thalassemia and myelodysplastic sindromes represent iron toxicity models with evidence of iron-related heart failure. Non-Transferrin-Bound Iron (NTBI), plays a key role in the pathogenesis of cardiac toxicity leading to the production of reactive oxygen species which increase lipid peroxidation (MDA). In acute myocardial infarction (MI) microvascular obstruction (MVO) and hemorrhage (HEM) are independent predictors of left ventricular (LV) remodelling. HEM may be a source of iron toxicity through NTBI and pro-inflammatory mediators (IL-6) , which can directly contribute to acute impairment of myocardial function and adverse LV remodelling.
The aim of the study was to assess NTBI in a consecutive cohort of patients (pts) prospectively enrolled with ST-elevation MI (STEMI).and its relationship with MVO and HEM.
Fifteen pts with STEMI were enrolled if the onset of symptoms had been < 12 hours before PCI. NTBI, MDA and IL-6 were assessed at admission and at 0-3-6-9-12-24 hours. Cardiac Magnetic Resonance imaging (CMR) was performed on a 1.5 T scanner at 5 days and 6 months after the cardiac event. Myocardial edema and HEM were assessed by T2 and T2* mapping. MVO, myocardial salvage and necrotic area were assessed by early and late gadolinium enhancement (LGE).
NTBI was detected in 13/15 pts with highest values in 4 pts with evidence of MVO and HEM. NTBI levels were significantly related to CK-MB and troponin T values. NTBI kinetic appears different in MVO and HEM (7/15 pts), with a peak values at 6 hours after PCI, in comparison with those with no evidence of MVO and HEM, in whom NTBI values were lower and remained indeterminable after the first 24 hours.
The detection of elevated NTBI values in pts with STEMI, MVO and HEM suggest a possible role of iron cardiotoxicity in myocardial damage.
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Roghi, A., Poggiali, E., Duca, L. et al. Evidence of non-transferrin-bound iron in patients with ST-elevation myocardial infarction: relationship with microvascular obstruction and post-reperfusion myocardial hemorrhage. J Cardiovasc Magn Reson 17, P118 (2015). https://doi.org/10.1186/1532-429X-17-S1-P118
- Acute Myocardial Infarction
- Cardiac Magnetic Resonance
- Late Gadolinium Enhancement
- Cardiac Magnetic Resonance Imaging