Volume 17 Supplement 1

Abstracts of the 18th Annual SCMR Scientific Sessions

Open Access

Aortic stiffness as a predictor of high-sensitivity cardiac troponin T levels at a chronic stage after ST-segment elevation myocardial infarction

  • Hans-Josef Feistritzer1,
  • Gert Klug1,
  • Sebastian J Reinstadler1,
  • Benjamin Seidner1,
  • Johannes M Mair1,
  • Michael Schocke2,
  • Wolfgang-Michael Franz1 and
  • Bernhard Metzler1
Journal of Cardiovascular Magnetic Resonance201517(Suppl 1):P127

https://doi.org/10.1186/1532-429X-17-S1-P127

Published: 3 February 2015

Background

Aortic stiffness is associated with early pulse wave reflection resulting in an increase of cardiac afterload and impairment of coronary perfusion. Experimental data show that high left ventricular pressure due to increased aortic stiffness is associated with enhanced myocardial cell death. We investigated whether aortic stiffness is related to high-sensitivity cardiac troponin T (hs-TnT) concentrations at a chronic stage 1 year after ST-segment elevation myocardial infarction (STEMI).

Methods

Seventy-four patients underwent cardiac magnetic resonance imaging for the assessment of left ventricular function, morphology, infarct size and aortic PWV 12 months after acute STEMI. Blood samples were drawn at 12 months by peripheral venipuncture. Hs-TnT levels were measured by a commercially available immunoassay (Roche Diagnostics®).

Results

hs-TnT concentrations (6.4 ng/L, IQR 5.0 - 8.6) were significantly associated with age (r = 0.417, p < 0.001), plasma creatinine levels (r = 0.257, p = 0.027), high-sensitivity-C-reactive protein levels (r = 0.281, p = 0.015) and aortic PWV (r = 0.435, p < 0.001). Multiple linear regression analysis revealed aortic PWV (ß = 0.349, p = 0.014) beside, plasma creatinine concentrations (ß = 0.288, p = 0.006) and diastolic blood pressure (ß = 0.243, p = 0.015) to be independently associated with hs-TnT concentrations (model: R = 0.622, p < 0.001).

Conclusions

Aortic stiffness is an indicator of prognosis after myocardial infarction. The present study suggests an impact of aortic stiffness on hs-TnT concentrations at 1 year after STEMI.

Funding

Austrian Society of Cardiology.

Authors’ Affiliations

(1)
University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck
(2)
Departement of Radiology I, Medical University of Innsbruck

Copyright

© Feistritzer et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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