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  • Open Access

Association of high-sensitivity cardiac troponin T concentrations with the left ventricular global function index after ST-segment elevation myocardial infarction

  • 1,
  • 1,
  • 1,
  • 1,
  • 1,
  • 2,
  • 1 and
  • 1
Journal of Cardiovascular Magnetic Resonance201517 (Suppl 1) :P134

https://doi.org/10.1186/1532-429X-17-S1-P134

  • Published:

Keywords

  • Percutaneous Coronary Intervention
  • Creatine
  • Left Ventricular Ejection Fraction
  • Creatine Kinase
  • Cardiac Magnetic Resonance

Background

The left ventricular global function index (LVGFI) is a novel indicator of cardiac performance. Recently, the LVGFI was linked to left ventricular ejection fraction and infarct characteristics in patients presenting with acute ST-segment elevation myocardial infarction (STEMI). In this study we sought to investigate the association of serially measured high-sensitivity cardiac troponin T (hs-TnT) concentrations and LVGFI assessed early after acute STEMI.

Methods

122 patients with first STEMI (mean age 58 ± 11 years) reperfused by primary percutaneous coronary intervention (p-PCI) were enrolled in this observational study. All patients underwent cardiac magnetic resonance (CMR) imaging within the first week after STEMI. Left ventricular dimensions and function were measured by cine true-FISP sequences. hs-TnT concentrations were assessed serially for up to 48 hours after p-PCI by a commercially available immunoassay. Fisher's r to z transformation was applied for comparison of correlation coefficients.

Results

The median delay to reperfusion was 205 min (IQR 144 to 391 min). The mean LVGFI was 35 ± 8 %. The median value of maximum hs-TnT concentrations was 5043 ng/l (IQR 2322 to 8104 ng/l). The LVGFI was significantly associated with maximum creatine kinase activity (r = -0.473, p < 0.001) and with maximum hs-TnT concentration (r = -0.478, p < 0.001). Statistically significant correlations were also detected between LVGFI and single time-point hs-TnT concentrations (all r < -0.422, all p < 0.001). Receiver operator characteristics analysis (area under the curve: 0.85, 95% CI 0.75 to 0.95) revealed hs-TnT concentrations measured 6 hours after p-PCI to most accurately predict a LVGFI below the median value of 34 %.

Conclusions

This study demonstrates that hs-TnT concentrations assessed serially after acute STEMI are associated with LVGFI. hs-TnT levels measured 6 hours after p-PCI best predicted a LVGFI below the median value.

Funding

Austrian Society of Cardiology.

Authors’ Affiliations

(1)
University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University of Innsbruck, Innsbruck, Austria
(2)
Departement of Radiology I, Medical University of Innsbruck, Innsbruck, Austria

Copyright

© Feistritzer et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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