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Biomarkers of hemodynamic stress and aortic stiffness post-STEMI: a cross-sectional analysis

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Journal of Cardiovascular Magnetic Resonance201517 (Suppl 1) :P146

  • Published:


  • Cardiovascular Magnetic Resonance
  • Natriuretic Peptide
  • Pulse Wave
  • Pulse Wave Velocity
  • Multiple Linear Regression Analysis


We aimed to evaluate the association between biomarkers of hemodynamic stress and aortic stiffness assessed at a chronic stage after ST-segment elevation myocardial infarction (STEMI).


Fifty-four patients four months after acute STEMI were enrolled in this cross-sectional, single-center study. N-terminal pro B-type natriuretic peptide (NT-proBNP), mid-regional pro-A-type natriuretic peptide (MR-proANP) and mid-regional pro-adrenomedullin (MR-proADM) levels were measured by established assays. Aortic stiffness was assessed by the measurement of pulse wave velocity using velocity-encoding, phase-contrast cardiovascular magnetic resonance imaging.


NT-proBNP, MR-proANP and MR-proADM concentrations were all correlated with aortic stiffness in univariate analysis (r = 0.378, r = 0.425, r = 0.532, all p < 0.005, respectively). In multiple linear regression analysis, NT-proBNP (ß = 0.316, p = 0.005) and MR-proADM (ß = 0.284, p < 0.020) levels were associated with increased aortic stiffness independently of age, blood pressure and renal function. In receiver operating characteristic analysis, NT-proBNP was the strongest predictor for high aortic stiffness (area under the curve: 0.82, 95% CI 0.67 - 0.96).


At a chronic stage after STEMI, concentrations of biomarkers for hemodynamic stress, especially NT-proBNP, are positively correlated with aortic stiffness. These biomarkers might also be useful as predictors of high aortic stiffness post-STEMI.


Austrian Society of Cardiology.

Authors’ Affiliations

University Clinic of Internal Medicine III, Cardiology and Angiology, Medical University Innsbruck, Innsbruck, Austria
Central Institute for Medical Laboratory Diagnostics, Medical University of Innsbruck, Innsbruck, Austria


© Reinstadler et al; licensee BioMed Central Ltd. 2015

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