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Intraindividual validation of 4D flow measurement against 2D flow measurements in aortas with bicuspid or tricuspid valves by cardiovascular magnetic resonance (CMR)
Journal of Cardiovascular Magnetic Resonance volume 17, Article number: P216 (2015)
Theoretically, blood flow in the ascending aorta of patients with helical flow patterns, as in patients with bicuspid aortic valves (BAV), are underestimated by routine two dimensional (2D) phase contrast velocity encoding (PC-VENC). Four dimensional (4D) PC-VENC is theoretically not influenced by flow patterns. Hence, both, 2D PC-VENC and 4D PC VENC should result in similar blood flow measurements in the ascending aorta of subjects without helical flow patterns, as in subjects with tricuspid aortic valves (TAV).
To test this hypothesis, we determined blood flow in the ascending aorta of sixteen patients with BAV and helical flow and eighteen healthy subjects with TAV and non-helical flow by 2D PC-VENC and 4D PC-VENC. Each data set was analyzed by two observers blinded to the other results.
In patients with BAV and helical flow, 4D PC-VENC resulted in systematically higher blood flow volumes than 2D PC-VENC. In subjects with TAV and non-helical flow, there was no systematical difference between 4D and 2D PC-VENC.
Helical flow patterns as in the ascending aorta of patients with BAV may be more correctly quantified by 4D-VENC compared to 2D PC-VENC.
All authors have no conflict of interest.
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Kharabish, A.E., Belker, K., Meierhofer, C. et al. Intraindividual validation of 4D flow measurement against 2D flow measurements in aortas with bicuspid or tricuspid valves by cardiovascular magnetic resonance (CMR). J Cardiovasc Magn Reson 17, P216 (2015). https://doi.org/10.1186/1532-429X-17-S1-P216
- Blood Flow
- Cardiovascular Magnetic Resonance
- Flow Measurement
- Tricuspid Valve
- Bicuspid Aortic Valve