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Dynamic changes of the extracellular matrix after acute tako-tsubo cardiomyopathy


We have recently demonstrated that cardiac energetic impairment and global myocardial edema persists for at least 4 months after an acute episode of Tako-tsubo cardiomyopathy (TTC). The aim of the current study was to evaluate the regional edema acutely and the status of the extracellular matrix at follow up


Eleven patients (10F, mean age 56±16yrs) with a clear diagnosis of ST-elevation TTC and emotional trigger were prospectively enrolled and underwent cardiac magnetic resonance acutely (day 0-3) and after 4 months on a Philips 3T Achieva scanner. Native 3-3-5 (MOLLI) T1 mapping was applied acutely, and both native and post-contrast T1 mapping were performed at 4 months follow-up. Eleven healthy controls underwent only native T1 mapping. T1 maps were: generated using in-house software - written in IDL (Exelis. Boulder CO, USA); quality controlled with chi-square maps; and imported into Segment (Medviso, Lund University, Sweden), where T1 values were generated for 16 segments. Extracellular volumes (ECV) were calculated for the follow-up scan using:

ECV=(1-hermatocrit)(ΔR1myocardium/ ΔR1blood)

Segments were grouped according to their wall motion (WM) on the acute scan (normal/abnormal).


From the acute to the follow-up scan, the LVEF improved from 54±12% to 66±6%, whereas LV mass index decreased from 77±15 g/m2 to 68±14 g/m2, both p<0.05.

At the acute scan, native T1 of abnormal WM segments was significantly longer compared with T1 from normal WM segments (1270±95 vs 1225±43 ms, p<0.05) and both were significantly increased compared to healthy controls (1188±16, p<0.05).

At the follow-up scan, ECV was increased to a similar extent both in segments that were dysfunctional and those that were normally contracting in the acute phase (33% and 34% respectively, p=0.05).


We demonstrate oedema in both normal and abnormally contracting segments in patients with acute TTC and a similar degree of extracellular expansion at follow-up.


Tenovus Scotland. Grant number G13/10.

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Ahearn, T., Jagpal, B., Cameron, D. et al. Dynamic changes of the extracellular matrix after acute tako-tsubo cardiomyopathy. J Cardiovasc Magn Reson 17 (Suppl 1), P259 (2015).

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