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Comparison of short and long axis T1 and ECV maps in patients with myocarditis
Journal of Cardiovascular Magnetic Resonance volume 17, Article number: P265 (2015)
T1 mapping and ECV imaging are promising diagnostic tools in patients with suspected myocarditis. However, there are currently no data on the potential influence of slice orientation on the derived T1 and ECV values. Thus, we compared global myocardial T1 and ECV values between slices with short and long axis orientation.
This study included 50 patients with clinically suspected myocarditis, who underwent CMR at 1.5 Tesla. T1 quantification was performed on three short (basis, center, apex) and on three long axis slices (2-, 3- and 4-chamber orientation), respectively. The modified Look-Locker inversion-recovery (MOLLI) sequence was used before and 15 minutes after administration of 0.075 mmol/kg Gadolinium-BOPTA. Native T1, post-contrast T1 and extracellular volume (ECV) maps were calculated using a dedicated plug-in written for the OsiriX software. Mean native and post-contrast T1 as well as ECV were obtained from the three short and long axes, respectively.
There were significantly lower median native myocardial T1 values on long axis slices (1079 (1040-1130.0)) compared to short axis slices (1103 (1069-1140); p=0.0026). However, there were no significant differences in post-contrast myocardial T1 values (median 554 (505-596) vs. 555 (509-601); p=0.2299) or ECV (median 30 (27-33) vs. 29 (26-33); p=0.6063) between short and long axis slices, respectively.
Slice orientation could be a potential confounding factor for the assessment of native global myocardial T1 values in myocarditis. Possible explanations for this finding include technical issues, such as variations in through-plane motion or partial-volume effects related to slice orientation, but also the heterogeneity of myocardial injury in myocarditis. However, our data indicate that global myocardial ECV values could be less sensitive to slice orientation.
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Bohnen, S., Radunski, U.K., Lund, G. et al. Comparison of short and long axis T1 and ECV maps in patients with myocarditis. J Cardiovasc Magn Reson 17, P265 (2015). https://doi.org/10.1186/1532-429X-17-S1-P265
- Myocardial Injury
- Potential Confounding Factor
- Axis Slice
- Lower Median