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T1 mapping by CMR in patients with arrhythmic cardiomyopathy
Journal of Cardiovascular Magnetic Resonance volume 17, Article number: P266 (2015)
Traditionally, late gadolinium enhancement (LGE) helps effectively detect focal fibrosis in cardiomyopathy. If patients have diffuse fibrosis, LGE could not provide enough objective evaluation of the severity of the disease. Arrhythmic cardiomyopathy (ACM) is a clinical entity which corresponds to all myocardial changes induced by chronic tachycardia. For ACM patients, myocardial fibrosis evaluation is important for treatment and prognosis. Accordingly, we aimed at exploring associations between myocardial T1 changes as a surrogate for left ventricular (LV) interstitial fibrosis in ACM.
Twenty-one patients with ACM underwent cardiac magnetic resonance (CMR) before catheter ablation. 19 healthy volunteers served as control group. CMR imaging was performed at 3.0T (Siemens MAGNETOM Verio) including cine, pre- and post-contrast T1 mapping, and LGE imaging. T1-maps were obtained in the same short-axis planes of LGE imaging before and 15minutes after the administration of gadolinium by using a modified Look-Locker (MOLLI) sequence. T1 times in 3 short axis slices (basal, mid-ventricular and apical) were evaluated.
ACM patients had the same age as control group (46.2±17.6 vs. 43.8±14.5, p=NS). Mean pre-contrast T1 time, post-contrast T1 time and reduced T1 time were significantly different in patients with ACM compared with control groups (1364.0±66.6 vs. 1292.9±69.0ms, 485.3±50.7 vs. 581.4±61.7ms, 878.7±97.0 vs. 624.9±166.4ms, all p<0.01). When the analysis was restricted to ACM patients without late gadolinium enhancement (LGE, n=16), these differences remained significant (figure).
Arrhythmic cardiomyopathy patients' myocardium show increased pre-contrast T1 times, decreased post-contrast T1 times and increased reductions in myocardial T1 times compared with healthy person. Abnormal myocardial T1 times, a surrogate of diffuse interstitial fibrosis, are found in arrhythmic cardiomyopathy.
Supported by the China National Natural Science Fund Grant (81101173).
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Zhao, L., An, J., Zhang, T. et al. T1 mapping by CMR in patients with arrhythmic cardiomyopathy. J Cardiovasc Magn Reson 17, P266 (2015). https://doi.org/10.1186/1532-429X-17-S1-P266
- Cardiac Magnetic Resonance
- Late Gadolinium Enhancement
- Catheter Ablation
- Interstitial Fibrosis
- Cardiac Magnetic Resonance Imaging