Skip to main content
  • Poster presentation
  • Open access
  • Published:

T1 mapping by CMR in patients with arrhythmic cardiomyopathy


Traditionally, late gadolinium enhancement (LGE) helps effectively detect focal fibrosis in cardiomyopathy. If patients have diffuse fibrosis, LGE could not provide enough objective evaluation of the severity of the disease. Arrhythmic cardiomyopathy (ACM) is a clinical entity which corresponds to all myocardial changes induced by chronic tachycardia. For ACM patients, myocardial fibrosis evaluation is important for treatment and prognosis. Accordingly, we aimed at exploring associations between myocardial T1 changes as a surrogate for left ventricular (LV) interstitial fibrosis in ACM.


Twenty-one patients with ACM underwent cardiac magnetic resonance (CMR) before catheter ablation. 19 healthy volunteers served as control group. CMR imaging was performed at 3.0T (Siemens MAGNETOM Verio) including cine, pre- and post-contrast T1 mapping, and LGE imaging. T1-maps were obtained in the same short-axis planes of LGE imaging before and 15minutes after the administration of gadolinium by using a modified Look-Locker (MOLLI) sequence. T1 times in 3 short axis slices (basal, mid-ventricular and apical) were evaluated.


ACM patients had the same age as control group (46.2±17.6 vs. 43.8±14.5, p=NS). Mean pre-contrast T1 time, post-contrast T1 time and reduced T1 time were significantly different in patients with ACM compared with control groups (1364.0±66.6 vs. 1292.9±69.0ms, 485.3±50.7 vs. 581.4±61.7ms, 878.7±97.0 vs. 624.9±166.4ms, all p<0.01). When the analysis was restricted to ACM patients without late gadolinium enhancement (LGE, n=16), these differences remained significant (figure).

Figure 1
figure 1

Arrhythmic cardiomyopathy patient's LGE and T1 mapping images. Upper lane are the LGE images in the basal, mid-cavity, and apical level, middle lane are the pre-contrast T1 mapping images, lower lane are the post-contrast T1 mapping images. No focal delayed enhancement lesions were found in the LGE images. The mean T1 value of pre-contrast images is 1430.6 ms, the mean T1 value of post-contrast images is 434.6 ms.


Arrhythmic cardiomyopathy patients' myocardium show increased pre-contrast T1 times, decreased post-contrast T1 times and increased reductions in myocardial T1 times compared with healthy person. Abnormal myocardial T1 times, a surrogate of diffuse interstitial fibrosis, are found in arrhythmic cardiomyopathy.


Supported by the China National Natural Science Fund Grant (81101173).

Author information

Authors and Affiliations


Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Zhao, L., An, J., Zhang, T. et al. T1 mapping by CMR in patients with arrhythmic cardiomyopathy. J Cardiovasc Magn Reson 17 (Suppl 1), P266 (2015).

Download citation

  • Published:

  • DOI: