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  • Poster presentation
  • Open Access

High signal intensity on T2 weighted cardiac magnetic resonance imaging in hypertrophic cardiomyopathy: Is it a marker of myocardial injury?

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Journal of Cardiovascular Magnetic Resonance201517 (Suppl 1) :P289

  • Published:


  • Cardiac Magnetic Resonance
  • Hypertrophic Cardiomyopathy
  • Myocardial Injury
  • Cardiac Magnetic Resonance Imaging
  • Cardiac Troponin


Previous studies observed the phenomenon of high signal intensity on T2 -weighted image of cardiac magnetic resonance imaging (CMR) in hypertrophic cardiomyopathy(HCM). However, the underlying histopathologic mechanism is unclear. Elevated cardiac troponin can be detected in some HCM patients. A reasonable hypothesis is that myocardial T2-high signals is a potential marker of myocaridal injury in HCM. We sought to investigate the association between cardiac troponin and the extent of T2-high signals in HCM patients.


Forty-four HCM patients underwent 3.0T CMR scanning. On T2-weighted images, the number of segments with high-signal intensity(myocardium to skeletal muscle signal intensity ratio>2)and the percentage of high-signal area (>2 SD above remote tissue) were measured in 16 myocardial segments along the LV mid-myocardial circumference on 3 short-axis images. The level of high sensitivity cardiac troponin T(hs-cTnT) was also assessed.


Myocardial T2-high signals were indentified in 33(75%)patients and 144(20.5%) segments.Elevated hs-cTnT was observed in 28(63.6%)patients.Cochran-Armitage test showed a statistically significant trend of increasing level of hs-cTnT with elevating number of segments with myocardial T2-high signal (p=0.002).Then,Pearson,s test showed the percentage of myocardium with T2-high signal significantly associated with the hs-cTnT level(r=0.388,P=0.009)


Myocardial T2-high signals can be considered as a marker of myocardial injury in HCM patients.
Figure 1
Figure 1

The relationship between the percentage of myocardium with T2-high signal and the level of high sensitivity cardiac troponin T(hs-cTnT)in patients with hypertrophic cardiomyopathy.

Table 1

Cardiac magnetic resonance characteristics of patients with HCM


Study participants (n=44)







LV mass,(g)


LV mass index,(g/m2)


Segments with T2-high signal, n(%)


Presence of T2-high signal, (%)


LVEDV, left ventricular end diastolic volume; LVESV, left ventricular end systolic volume; LVEF, left ventricular ejection fraction;LV left ventricle

Authors’ Affiliations

West China Hosptial, Chengdu, China
Department of Cardiovascular Ultrasound and Noninvasive Cardiology, Sichuan Academy of Medical Sciences and Sichuan People's Hospital, Chengdu, Chengdu, China
MR Collaborations NE Asia, Siemens Healthcare, Beijing, China


© Chen et al; licensee BioMed Central Ltd. 2015

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.