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T1 mapping, ECV and ICV before and after aortic valve replacement

Background

the aim of the study was to assess T1 mapping using T1 values, extracellular volume (ECV) and intra cellular volume (ICV) with cardiovascular magnetic resonance (CMR) in patients with surgical aortic stenosis before and after surgery.

Methods

A prospective CMR T1 mapping study of 37 patients with severe AS before and six months after aortic valve replacement (AVR) was conducted. CMR at 1.5 T, including T1 mapping using a modified Look-Locker inversion recovery sequence (before and 15 minutes after the administration of 0.2 mmol/kg of Gadoteric acid), was carried out. Global T1 values, ECV, ICV have been measured before and six months after surgery.

Results

After AVR, post contrast T1 values were significantly lower compared to before surgery (443 ± 18 ms versus 460 ± 19 ms; p=0,027). ECV was significantly higher after surgery (27,9 ± 4,7 % versus 25,1 ± 2,7 %; p = 0.0001). Reciprocally, ICV significantly decreased after surgery (74,9 % versus 72,1 % p = 0.0001). In parallel, myocardial mass (89.5 ± 27 g/m2 versus 74.5 ± 23 g/m2 ; p<0,001), end diastolic volume (74 ± 19 ml/m2 versus 65 ± 12 ml/m2 ; p<0,001) and septal thickness (15 ± 2.5 mm versus 14 ± 2.5 mm ; p<0,001) decreased significantly after surgery.

Conclusions

Post contrast T1 values, ICV, myocardial mass and septal thickness significantly decreased after AVR, suggesting that LV hypertrophy regression is more cellular than interstitial fibrosis regression. Larger studies are needed to confirm these data.

Funding

No funding.

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Correspondence to Emmanuelle Vermes.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Vermes, E., Cazeneuve, N., Genee, O. et al. T1 mapping, ECV and ICV before and after aortic valve replacement. J Cardiovasc Magn Reson 17, P342 (2015). https://doi.org/10.1186/1532-429X-17-S1-P342

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Keywords

  • Cardiovascular Magnetic Resonance
  • Aortic Stenosis
  • Aortic Valve Replacement
  • Inversion Recovery
  • Interstitial Fibrosis