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The role of cardiac MR in identifying annulus paradoxus, a specific marker for constrictive pericarditis

Background

Distinguishing constrictive pericarditis from restrictive cardiomyopathy can be challanging. In normal subjects and many cardiac pathologies, the lateral mitral annulus compared to medial demonstrates more longitudinal excursion. This is due to the presence of more longitudinal fibres and lubrication offered by pericardium. Annulus paradoxus is a term used to define reversal of this phenomenon due to tethering of the pericardium and has been extensively reported as a specific marker of constrictive pericarditis in echocardiography by using tissue doppler imaging (TDI). TDI is a pulse wave doppler technique and has limitations due to aliasing and angle of interrrogation. We define an alternative way of demonstrating this phenomenon on CMR that will provide additive diagnostic power due to better spatial resolution.

Methods

64 retrospective patients were included in the study. 23 of these had CMR and surgical diagnosis of constrictive pericarditis. Of the remaining 41 patients, 19 were diagnosed as normal and 22 had alternative diagnoses of non-ischaemic cardiomyopathies (Restrictive cardiomypathy, hypertrophic cardiomyopathy, ARCV, non.compaction, Fabry's disease and dilated cardiomyopathy). We identified annular excursion by longitudinal motion of the medial and lateral mitral annulus in a 4 chamber SSFP view perpendicular to the transverse plane. Annular excursion was measured in end diastole and end systole. Annular excursion differences were calculated by subtracting the lateral annular excursion from that of the medial during the diastole and systole. A negative value indicated paradoxical motion. We excluded studies with known wall motion abnormalities, severe valvular heart diease, prosthetic heart valves and poor image resolution due artifacts.

Results

18 (78%) of the patients with constrictive disease had paradoxical excursion of the mitral valve annulus. Mean annular excursion difference was -0.88 (-5.6 to 3.57).

Of those without constrictive disease 37 (90%) did not show annulus paradoxus. This included 84% of the normal patients and 95% of those with other diagnoses. In this non-constrictive group the mean annular excursion difference was 2.31 (-1.9 to 6.37)(p<0.05 compared to constrictive group). Normal group: 2.41(-1.93 to 5.61). Other diagnosis group: 2.45 (-0.82 to 6.37).

Using negative annular excursion differences on MRI (annulus paradoxus) for constrictive cardiac disease our results showed a sensitivity of 78%, specificity of 90%, positive predictive value of 82% and negative predictive value of 88%.

Conclusions

This study shows that annulus paradoxus is a specific and highly reproducible marker of constrictive pericarditis that can be accuratly estimated from 4 chamber SSFP cine CMR images. Unlike echocardiography, we are not dependent on body habitus and opertor skill to obtain high quality images and perform doppler interrogation.

Funding

None.

Figure 1
figure1

Scatter plot of excursion differences in the three groups

Table 1 Mean annular motion and differences.

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Correspondence to Kashif Kalam.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Kalam, K., Harmse, W., Merchant, N. et al. The role of cardiac MR in identifying annulus paradoxus, a specific marker for constrictive pericarditis. J Cardiovasc Magn Reson 17, P362 (2015). https://doi.org/10.1186/1532-429X-17-S1-P362

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Keywords

  • Cardiomyopathy
  • Dilate Cardiomyopathy
  • Hypertrophic Cardiomyopathy
  • Tissue Doppler Imaging
  • Constrictive Pericarditis