Shared versus non-shared prepulse perfusion MR sequence in absolute myocardial perfusion quantification
Journal of Cardiovascular Magnetic Resonance volume 17, Article number: P43 (2015)
First-pass perfusion cardiac magnetic resonance (CMR) allows the quantitative assessment of myocardial blood flow (MBF). Currently, clinical translation is lacking, mainly due to considerable disparity in quantification methodology. The aim of this study was to compare shared (SP) and non-shared (NSP) prepulse perfusion MR sequences for MBF quantification.
In this substudy of the NOMI-trial (ClinicalTrials.gov identifier: NCT01398384), quantitative perfusion analysis was compared between patients that underwent an MR first pass perfusion sequence with a shared (n=25) and a non-shared prepulse (n=25), at 4 months after revascularized myocardial infarction. Perfusion imaging consisted of 3 short-axis slices acquired every heartbeat, with a balanced turbo gradient echo sequence in a 1.5 tesla MR unit (Achieva, Philips Medical Systems, The Netherlands) and was performed at rest and during adenosine (140 µg/kg/min) stress. MBF was quantified using Fermi deconvolution with a single bolus (SB, 0.05 mmol/kg) and dual bolus (DB, equal volumes of 0.0027 mmol/kg followed by 0.05 mmol/kg of contrast agent) analysis technique, in 6 segments of basal and midventricular short axis slices. Apical segments and segments with infarct scar on the corresponding late gadolinium enhancement-images were excluded.
Baseline characteristics of both patient groups were comparable. MBF values were significantly higher with SP than with NSP sequence for the SB analysis technique. For DB, MBF was not different for rest perfusion, but MBF during stress perfusion was significantly lower with SP than with NSP sequence. At a contrast dose of 0.05 mmol/kg, the relationship between signal intensity and contrast agent concentration is subject to saturation in both the left ventricular (LV) luminal and myocardial signal intensity curves. In the SB technique, saturation of the LV luminal signal intensity curve predominates the analysis result, with overestimation of MBF. In the DB technique, saturation of the myocardial signal intensity curve becomes relevant when MBF is high (stress perfusion), resulting in underestimation of MBF.
To minimize saturation effects in myocardial perfusion quantification, a NSP MR sequence is preferable over SP. Both SB and DB analysis techniques are subject to saturation, especially at high MBF. Future MR sequence developments towards more stable and non-saturated signal intensities are needed.
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Goetschalckx, K., Rademakers, F.E., Bogaert, J. et al. Shared versus non-shared prepulse perfusion MR sequence in absolute myocardial perfusion quantification. J Cardiovasc Magn Reson 17 (Suppl 1), P43 (2015). https://doi.org/10.1186/1532-429X-17-S1-P43