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In vitro evaluation of flow patterns and turbulent kinetic energy in trans-catheter aortic valve prostheses
© Giese et al; licensee BioMed Central Ltd. 2015
- Published: 3 February 2015
- Flow Pattern
- Turbulent Kinetic Energy
- Ventricular Assist Device
- Valve Prosthesis
- Flow Waveform
Trans-catheter aortic valve implantation (TAVI) has emerged as an alternative to open heart surgery for valve replacement. Hemodynamics in these bioprostheses however still differ from physiological conditions. Multi-venc phase-contrast MRI is known to allow the quantification of flow parameters and recent developments enable the quantification of turbulent kinetic energy (TKE). Turbulent flows do not generally occur under physiological conditions and are known to lead to an increased workload for the heart. In the present work, highly accelerated multi-venc phase-contrast MRI is used to compare flow patterns and TKE values in different TAVI prostheses in a pulsatile in-vitro model.
Three different TAVI prostheses were measured using highly accelerated 3D phase-contrast MRI in a 3T Achieva (Philips Medical) system using a 6-channel cardiac coil. Physiological pulsatile flow waveforms were achieved using a conventional ventricular assist device (VAD). The prostheses were positioned in a flexible PVC tube (diameter: 19 mm). Blood-like viscosity was achieved by using a glycerol (40%) and water (60%) mixture. Multi-venc acquisition parameters included venc: 350&70&40cm/s, Δx=1.5mm3, Δt=40ms, undersampling factor:8. Measurements were reconstructed using k-t Principal Component Analysis (k-t PCA) and unfolded using a Bayesian approach allowing for concurrent flow and TKE calculations. Analysis was performed using GTFlow (Gyrotools).
Highly undersampled multi-venc 3D phase-contrast MRI allows for the evaluation of time-resolved 3D flow parameters, flow patterns as well as the quantification of turbulent kinetic energy. The first acquisition of TKE values in TAVI prostheses demonstrated different flow patterns and TKE values for 3 different prostheses. The acquisition time of under 10 minutes allows future work to include in vivo acquisitions of healthy subjects and patients prior and following TAVI implantation.
Supported by the Koeln Fortune Program / Faculty of Medicine, University of Cologne.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.