- Walking poster presentation
- Open Access
Single breathhold, three-dimensional measurement of left atrial volume and function using sparse CINE CMR imaging with iterative reconstruction
© Monney et al; licensee BioMed Central Ltd. 2015
- Published: 3 February 2015
- Left Atrial
- Phantom Study
- Calculated Volume
- Left Atrial Volume
- Single Breath Hold
Left atrial (LA) dilatation is associated with a large variety of cardiac diseases and many LA pathologies go along with an adverse prognosis. A time-efficient 3D CMR method to precisely measure the LA volumes and function is therefore highly desirable.
A highly accelerated prototype cine sequence with sparse sampling and Iterative Reconstruction (sCINE-IR) was used in phantoms and patients to acquire 5 cine slices (2 long axis, LAX and 3 short axis, SAX) through the LA during a single breathhold yielding a spatial/temporal resolution of 1.5mm/30ms (1.5T Aera, Siemens AG, Germany). The LA volumes were reconstructed from these 5 slices using a non-model based method (Bermano A, ACM trans Graph 2011). As a reference in patients, a self-navigated high-resolution whole-heart 3D dataset (3D-HR) was acquired during mid-diastole, from which the LA volume was segmented. Phantom study. Five LA phantoms made of solanum tuberosum L of known volume (water displacement method) and of different shapes were imaged with both 3D-HR and CS in various slice orientations and the calculated volumes were compared. Patients study. Three patients were scanned with both 3D-HR and sCINE-IR. The volumes obtained with 3D-HR and with sCINE-IR during the corresponding mid-diastolic frame were compared using Bland-Altman method and linear regression.
With this new method of a highly accelerated sCINE-IR acquisition followed by a 3D non-model based reconstruction, LA volumes could be accurately measured from 5 cine slices acquired during one single breath hold. This method opens the possibility to precisely measure LA function over time. The reproducibility of this new technique needs to be assessed on a larger patient cohort.
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