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Low T2-star (T2*) Signals in cardiac MR imaging in patients with dilated cardiomyopathy and sarcoidosis


T2 star (T2*)-weighted MR imaging can be utilized to semi-quantitatively analyze tissue iron content. Excessive cardiac iron may aggravate cardiac performance, however, little is known about the T2* signal intensity in myopathic heart. We analyzed T2* signal intensity in primary and secondary cardiomyopathy.


We enrolled 11 non-cardiomyopathic and 93 cardiomyopathic patients with following diagnoses: hypertensive or hypertrophic cardiomyopathy (n=22), dilated cardiomyopathy (n=28), sarcoidosis (n=13), old myocardial infarction (n=7), and other form of cardiomyopathy (n=23). Using 3-Teslar cardiac MRI (SignaHDxt, GE medical), T2* signal intensity in the cardiac ventricular septum and hepatic parenchyma were measured.


Compared with the cardiac T2* values in non-cardiomyopathic group (25.7±5.7 msec), those in hypertrophic cardiomyopathy or hypertensive cardiomyopathy (24.6±7.9 msec) did not differ significantly, however, those in the dilated cardiomyopathy (20.6±5.6 msec, P < 0.01) and sarcoidosis (18.0±3.2 msec, P < 0.01) were significantly lower. On the other hand, liver T2* values, as well as serum ferritin and iron concentrations, in patients with dilated cardiomyopathy or those with sarcoidosis did not differ those in the non-cardiomyopathic group.


Cardiac T2* signal intensity was lower in the heart of dilated cardiomyopathy and sarcoidosis. Whether excessive iron in these forms of cardiomyopathy aggravates cardiac performance through generating noxious reactive oxygen species needs further investigation.



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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Kanzaki, Y., Yuki, M. & Ishizaka, N. Low T2-star (T2*) Signals in cardiac MR imaging in patients with dilated cardiomyopathy and sarcoidosis. J Cardiovasc Magn Reson 17 (Suppl 1), Q73 (2015).

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