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Collateral flow quantification by cardiovascular magnetic resonance during continuous submaximal exercise in patients with total cavo-pulmonary connection
© Mkrtchyan et al; licensee BioMed Central Ltd. 2015
- Published: 3 February 2015
- Blood Flow
- Cardiovascular Magnetic Resonance
- Physical Exercise
- Inferior Vena
- Collateral Flow
Collateral flow is often described in patients with total cavo-pulmonary connection (TCPC). However, the amount of collateral flow in rest and during exercise is unclear. Therefore, the aim of this study was to quantify collateral flow in rest and during continuous submaximal exercise in clinically well doing patients with TCPC.
Blood flows in the aorta ascendens, aorta descendens, inferior vena cava, and superior vena cava were measured at rest and during continuous submaximal physical exercise by cardiovascular magnetic resonance in 13 patients with TCPC (19±7 yrs.) and 13 age and sex-matched healthy controls (20±8 yrs.).
TCPC patients had significantly lower systemic blood flow(Qs) at rest (2.7±0.6 vs. 3.6±0.7 L/min/m2, p<0.001) and during exercise (3.4±1.0 vs. 4.9±0.9 L/min/m2, p<.0001), than healthy controls. The increase in Qs with exercise was also significantly lower in patients, than in healthy controls (0.6 vs. 1.2 L/min/m2, p<0.02). Absolute collateral flow did not change in TCPC patients during exercise compared to rest (0.4±0.3 vs. 0.5±0.4 L/min/m2, p=0.97).
Clinically well doing patients with TCPC have significant collateral flow at rest (17% of Qs) that does not change during submaximal exercise (14% of Qs).
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