Skip to main content

Volume 18 Supplement 1

19th Annual SCMR Scientific Sessions

  • Oral presentation
  • Open access
  • Published:

HIV-1-related cardiovascular disease is associated with chronic inflammation, frequent pericardial effusions and increased myocardial oedema


Treatment for HIV has been associated with a near-normal life expectancy, though with increased cardiac morbidity and mortality. Mechanisms of heart disease in patients infected with HIV remain unclear. Coronary artery disease and myocardial dysfunction may be partly related to untreated chronic inflammation. Cardiovascular magnetic resonance (CMR) imaging allows a comprehensive assessment of myocardial structure, function and tissue characterization. We investigated, using CMR, the presence of subclinical cardiac inflammation and myocardial disease in asymptomatic HIV-infected individuals.


Myocardial structure and function were assessed using CMR at 1.5 Tesla in treated HIV-infected individuals without overt cardiovascular disease (n = 103, mean age 45 ± 10 years), compared to healthy controls (n = 92, mean age 44 ± 10 years). Assessments included left ventricular volumes, ejection fraction, strain, regional systolic, diastolic function, native T1 mapping, oedema and gadolinium enhancement. CMR imaging biomarkers were correlated with serum hs-CRP and markers of HIV severity.


Compared to controls, subjects with HIV infection had 4% lower left ventricular ejection fraction (< 0.001), 7% higher myocardial mass (p = 0.02) and 41% lower peak diastolic strain rate (p < 0.001). Compared to controls, subjects with HIV had 4% higher STIR values and 8% were above the set STIR threshold of 40 mm2. There were higher native T1 values in subjects with HIV (969 ms ± 28 versus 956 ± 24 in controls, p = 0.01,). There were greater numbers of subjects with HIV above a set T1 threshold of 990 ms, compared to controls (9% vs. 3%, p < 0.001). Pericardial effusions and myocardial fibrosis was three and four times more common, respectively, in subjects with HIV infection, compared to controls (both p < 0.001).


Treated HIV infection is associated with changes in myocardial structure and function, in addition to higher rates of subclinical myocardial oedema and frequent pericardial effusions. Chronic systemic inflammation in HIV, which involves the myocardium and pericardium, may explain the high rate of myocardial fibrosis and increased cardiac dysfunction in people living with HIV.

Figure 1
figure 1

CMR findings.

Author information

Authors and Affiliations


Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ntusi, N.A., O'Dwyer, E., Dorrell, L. et al. HIV-1-related cardiovascular disease is associated with chronic inflammation, frequent pericardial effusions and increased myocardial oedema. J Cardiovasc Magn Reson 18 (Suppl 1), O104 (2016).

Download citation

  • Published:

  • DOI: