- Oral presentation
- Open Access
4D Multiphase steady state imaging with contrast (MUSIC) enhancement using ferumoxytol: a new paradigm in pediatric congenital heart disease
© Nguyen et al. 2016
- Published: 27 January 2016
- Congenital Heart Disease
- Correlative Imaging
- Breath Holding
- Diagnostic Image Quality
- Complex Congenital Heart Disease
CMR in children with congenital heart disease (CHD) often requires expert physician supervision and long examination times. Further, the complex anatomy may not be fully defined with limited 2D slices at the time of image acquisition and missing slice orientations cannot be reconstructed retrospectively. 4D MUSIC (1) generates isotropic high-resolution 3D images over multiple, independent cardiac phases without breath holding. We aim to evaluate this technique in patients with complex CHD and compare it to breathe held contrast enhanced MRA (CE-MRA) and 2D cine.
Forty-three children (age 3 days to 19 years; weight 1.2 kg to 62 kg) with suspected or known complex CHD underwent ferumoxytol-enhanced CMR on a 3.0T MRI system between 2013 and 2015. Two readers with advanced CMR training scored the diagnostic image quality of named intra-cardiac structures and multiple vascular segments including the coronary arteries using a four-point scale. Surgery, correlative imaging or autopsy confirmed MUSIC MRI findings. Quantitative volumetric measurements derived from 4D MUSIC and conventional 2D cine images were compared.
There were no adverse reactions to ferumoxytol. Intra-cardiac and vascular anatomy were significantly better visualized (p < 0.001) with MUSIC than with breath held CE-MRA. Coronary artery anatomy was routinely visualized with high confidence on MUSIC images. Quantitative volumetric measurements derived from 4D MUSIC and conventional 2D cine imaging were strongly correlated (r = 0.99, p < 0.001) and concordance with correlative imaging, surgical findings and /or autopsy results was excellent.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.