Skip to main content

Volume 18 Supplement 1

19th Annual SCMR Scientific Sessions

  • Oral presentation
  • Open access
  • Published:

Prognostic value of MRI T2 quantification in heart transplant patients: a 5-year outcome study


Endomyocardial biopsy (EMB) is the current gold standard to monitor patients for heart transplant rejection. Quantification of myocardial T2 relaxation time using cardiac magnetic resonance (CMR) has been shown to have high sensitivity and specificity to detect rejection episodes. In this study, we evaluated the prognostic value of myocardial T2 to predict adverse cardiovascular outcomes during 5-year follow-up after initial CMR.


49 cardiac transplant patients (mean age, 48 ± 14 years; 65% male) were recruited from a single institution. CMR at 1.5T was performed in all patients, with subsequent quantifications of regional and global myocardial T2. Clinical data was gathered post-CMR over a 5-year period. EMBs were graded according to the International Society of Heart & Lung Transplantation criteria. Rejection episodes were defined by EMB ≥ 2R, new onset heart failure (HF), LV ejection fraction < 40%, or death. Adverse cardiovascular events gathered included coronary artery disease, cardiomyopathies, arrhythmias, and different types of HFs. Multivariable logistic regression and Kaplan-Meier analysis was performed to measure the prognostic value of myocardial T2.


Myocardial T2 was found to increase with worsening EMB grade from 53.0 ms (0R, no rejection) to 59.9 ms (3R, severe rejection). ROC analysis using two groups (EMBs ≤ 1R and ≥ 2R) showed T2 = 55.0 ms to have the highest specificity and sensitivity. In multivariable analysis that considered T2 measures, age, length of surgery, donor ischemic time, and BMI, both peak T2 (p = 0.038) and septal T2 (p = 0.035) were significant predictors of EMB grade ≥ 2R. Kaplan-Meier analysis showed a significant higher probability of developing EMB ≥ 2R, new onset HF, or death with a global T2 ≥ 55 (p = 0.02). Adverse cardiovascular outcomes of systolic HF, acute systolic HF, and chronic diastolic HF had a higher probability of developing in patients with global T2 ≥ 55 (p = 0.01, p = 0.01, and p < 0.01, respectively).


CMR T2 quantification demonstrated prognostic value for all-cause rejection and various types of HFs in cardiac transplant patients. These findings suggest that CMR may be a suitable modality to non-invasively monitor cardiac transplant patients for rejection.

Figure 1
figure 1

Kaplan-Meier survival curves for all-cause rejection episodes according to T2 quantification values. T2 values are dichotomized as ≥55 ms (n = 10, 7 positive outcomes) and <55 ms (n = 38, 18 positive outcomes). Significance level for this composite outcome was 0.02. Factor has units of ms.

Figure 2
figure 2

Kaplan-Meier survival curves for systolic HF episodes according to T2 quantification values. T2 is dichotomized as ≥55 ms (n = 10, 5 positive outcomes) and <55 ms (n = 39, 6 positive outcomes). Significance level for this composite outcome was 0.01. Factor has units of ms.

Author information

Authors and Affiliations


Rights and permissions

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Chowdhary, V., Barfuss, S., Gao, Y. et al. Prognostic value of MRI T2 quantification in heart transplant patients: a 5-year outcome study. J Cardiovasc Magn Reson 18 (Suppl 1), O34 (2016).

Download citation

  • Published:

  • DOI: