Occult senile cardiac amyloid in severe calcific aortic stenosis is not rare and has a poor prognosis: a 146 patient CMR biopsy study

Table 1 Pre-operative characteristics of patients with TTR on cardiac biopsy

	Patient 1	Patient 2	Patient 3	Patient 4	Patient 5	Patient 6
Age/Gender	73 female	69 male	80 female	85 male	84 male	71 male
Biopsy/Genotype	TTR/wild-type	TTR/wild-type	TTR/wild-type	TTR/wild-type	TTR/wild-type	TTR/wild-type
CMR LGE pattern*	Amyloidosis	Amyloidosis	AS	AS	AS	AS
ECV	60%	52%	31%	25%	32%	32%
LV mass index (g/m ² )	137	150	117	101	93	132
DPD Scintigraphy	Grade 2	Grade 2	NA	Grade 1	NA	Grade 1
Peak AV Gradient (mmHg)	74	45	70	110	61	116
AVAi (cm ² /m ² )	0.36	0.52	0.6	0.34	0.35	0.24
Follow-up Status	Alive	Dead	Dead	Alive	Dead	Alive

*LGE pattern consistent with diagnosis of cardiac amyloidosis / aortic stenosis (AS)

ISSN: 1532-429X