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Table 1 Pre-operative characteristics of patients with TTR on cardiac biopsy

From: Occult senile cardiac amyloid in severe calcific aortic stenosis is not rare and has a poor prognosis: a 146 patient CMR biopsy study

  Patient 1 Patient 2 Patient 3 Patient 4 Patient 5 Patient 6
Age/Gender 73 female 69 male 80 female 85 male 84 male 71 male
Biopsy/Genotype TTR/wild-type TTR/wild-type TTR/wild-type TTR/wild-type TTR/wild-type TTR/wild-type
CMR LGE pattern* Amyloidosis Amyloidosis AS AS AS AS
ECV 60% 52% 31% 25% 32% 32%
LV mass index (g/m 2 ) 137 150 117 101 93 132
DPD Scintigraphy Grade 2 Grade 2 NA Grade 1 NA Grade 1
Peak AV Gradient (mmHg) 74 45 70 110 61 116
AVAi (cm 2 /m 2 ) 0.36 0.52 0.6 0.34 0.35 0.24
Follow-up Status Alive Dead Dead Alive Dead Alive
  1. *LGE pattern consistent with diagnosis of cardiac amyloidosis / aortic stenosis (AS)