- Poster presentation
- Open Access
T1 mapping using a saturation recovery single-shot acquisition at 3 Tesla MRI in differentiation of normal myocardium from hypertrophic cardiomyopathy
© Ogawa et al. 2016
- Published: 27 January 2016
- Cardiac Magnetic Resonance
- Hypertrophic Cardiomyopathy
- Myocardial Fibrosis
- Discriminative Ability
- Normal Myocardium
Background Diffuse myocardial fibrosis is characteristic feature of hypertrophic cardiomyopathy (HCM). T1 mapping may enable non-invasive evaluation of diffuse myocardial fibrosis in HCM. There have been many studies that T1 mapping using a modified Look-Locker inversion recovery (MOLLI) sequence. However, there have been few studies using a SASHA for T1 mapping at 3 Tesla MRI. The purpose of this study was to examine T1 values using a SASHA, in the differentiation between healthy controls and HCM patients.
The clinical diagnosis of HCM was established via echocardiography, Cardiac Magnetic Resonance, electrocardiogram, laboratory examination, family history and other clinical data. Twenty patients with HCM and ten healthy controls, underwent left-ventricular T1 mapping in 3 short-axis slices (basal, mid, apex) at 3 Tesla MRI (Philips Achieva). For T1 mapping, SASHA was used before and at 10 minutes after injection of 0.1 mmol/kg of gadolinium contrast. T1 values were quantified for 4 segments (anterior, lateral, septum, inferior) of 3 short-axis slices.
Native T1 values were significantly longer in HCM compared with healthy controls (HCM 1377 ± 72 ms vs healthy controls 1285 ± 49 ms; p < 0.01). Post-contrast T1 values were significantly shorter in HCM compared with healthy controls (HCM 840 ± 64 ms vs healthy controls 908 ± 94 ms; p < 0.01). A cutoff value of 1363 ms for native T1 values allowed differentiation between healthy and abnormal segments (HCM) with a sensitivity of 57%, specificity of 92%, accuracy of 69%, and an area under the curve (AUC) of 0.77. On the other hand, post-contrast T1 values showed lower discriminative ability than native T1 values.
T1 values in HCM and healthy controls
native T1 values (ms) (median ± quartile deviation)
post T1 values (ms) (median ± quartile deviation)
HCM (240 segments)
1377 ± 72
840 ± 64
healthy controls (120 segments)
1285 ± 49
908 ± 94
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.