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Volume 18 Supplement 1

19th Annual SCMR Scientific Sessions

  • Poster presentation
  • Open Access

Myocardial T1 mapping in asymptomatic subjects: variations according to left ventricular segments and correlation with cardiovascular risk factors

  • 1,
  • 1,
  • 1,
  • 1,
  • 1 and
  • 2
Journal of Cardiovascular Magnetic Resonance201618 (Suppl 1) :P119

https://doi.org/10.1186/1532-429X-18-S1-P119

  • Published:

Keywords

  • Cardiovascular Risk Factor
  • Left Ventricular Mass
  • Myocardial Segment
  • Asymptomatic Subject
  • Apical Segment

Background

To evaluate whether there is variation in precontrast and postcontrast myocardial T1 time (prT1 and poT1, respectively) and extracellular volume fraction (ECVF) according to left ventricular (LV) segments and to search for any correlation between them and known cardiovascular risk factors.

Methods

This study included 198 asymptomatic subjects (180 men and 18 women, age 54.4 ± 6.12 years) who underwent cardiac MR imaging. Precontrast T1 mapping and postcontrast T1 mapping 15 minutes after 0.2 mmol gadobutrol injection were performed using shortened modified look-locker inversion recovery [ShMOLLI] sequence at 1.5T (Magnetom Avanto, Siemens). Short-axial cine MR imaging was performed with SSFP technique. T1 values and ECVFs were calculated in 16 AHA myocardial segments. Those values were compared among LV segments and correlated with presence of hypertension (n = 52), diabetes mellitus (DM, n = 15), or both (n = 17). ECVF was also correlated with LV mass.

Results

The overall prT1 and poT1 values and ECVF were 1006 ± 291.5 ms, 454.2 ± 38.5 ms, and 0.24 ± 0.04, respectively. There was significant difference between apical segments and mid-basal segments in poT1 value and ECVF (p < 0.03) and between mid-septal segments and mid-lateral segments in T1 values and ECVF (p <0.04). ECVF showed reverse correlation with LV mass (p = 0.002). There was significantly lower poT1 value (449 ± 35.6 ms) and higher ECVF (0.24 ± 0.04) in subjects with hypertension compared with those (459 ± 43.3 ms and 0.23 ± 0.02) of subjects without hypertension (p < 0.05). Subjects with DM showed no difference in all T1 values from subjects without DM or hypertension, except poT1 values in mid-septal segments (447 ± 23.6 ms vs 459 ± 45.6 ms, p = 0.02). Subjects with both risk factors showed no difference in all T1 values from subjects without DM or hypertension, except prT1 value between apical septal and lateral segments (1007 ± 126 ms vs 999 ± 156 ms, p = 0.03).

Conclusions

The septal wall showed higher prT1 value and ECVF but lower poT1 value than the lateral wall of mid- and basal levels. PoT1 value and ECVF are significantly affected by hypertension and LV mass.

Authors’ Affiliations

(1)
Radiology, Samsung Medical Center, Seoul, Korea (the Republic of)
(2)
Cardiology, Samsung Medical Center, Seoul, Korea (the Republic of)

Copyright

© Kim et al. 2016

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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