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LV geometric and substrate remodelling in patient with Ebstein anomaly - a deep insight from MRI T1 mapping fibrosis imaging
Journal of Cardiovascular Magnetic Resonance volume 18, Article number: P159 (2016)
Ebstein anomaly is a kind of congenital defect of tricuspid valve mainly affecting the right ventricle, recent evidence have suggested the LV geometry remodeling in patient with Ebstein anomaly due to potential RV-LV coupling. The aim of this study-we investigated the interaction between abnormal right ventricle and left ventricle and whether myocardial fibrosis is the basis of abnormal left ventricle remodeling in ebstein abnomaly by using T1 mapping technique of cardiac magnetic resonance.
Twenty patients with ebstein's anomaly and twenty matched normal controls were prospectively included in this study. All subjects received a comprehensive cardiac MRI scanning according to a standard protocol, which consisted of pre- and post-contrast T1 mapping for calculating ECV to quantify myocardial fibrosis of left ventricle. LV geometry and function data. Bi-ventricular volume, function and severity of ebstein anomaly were also analyzed.
In patients with Ebstein anomaly, LV volume was mildly decreased and EF also mildly reduced .ECV of LV myocardium in ebstein was larger than that of normal controls (28.76 ± 4.40 vs 23.39 ± 3.56 p = 0.003). ECV correlated well with severity index of RV malformation and LVEF in Ebstein's patients group. The native-T1 value of LV myocardium in ebstein's was longer than that of in normal controls with p = 0.04.
LV myocardial fibrosis and remodeling evidently existed in patients with ebstein's anomaly which was strongly correlated to the severity index of ebstein. Myocardial fibrosis plays a role in LV remodeling which directly results from LV deformity in ebstein' patients.
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Yang, D., Sun, J., Wan, K. et al. LV geometric and substrate remodelling in patient with Ebstein anomaly - a deep insight from MRI T1 mapping fibrosis imaging. J Cardiovasc Magn Reson 18 (Suppl 1), P159 (2016). https://doi.org/10.1186/1532-429X-18-S1-P159
- Cardiac Magnetic Resonance
- Tricuspid Valve
- Myocardial Fibrosis
- Left Ventricle Remodel
- Ebstein Anomaly