- Poster presentation
- Open Access
Atrial scar on late gadolinium-enhanced imaging to predict electrical reconnection after pulmonary vein isolation for atrial fibrillation
© Cochet et al. 2016
- Published: 27 January 2016
- Pulmonary Vein Isolation
- Atrial Fibrillation Recurrence
- Scar Burden
- turboFLASH Sequence
- Blood Pool Signal
Atrial fibrillation (AF) recurrences after pulmonary vein isolation (PVI) have been related to transient blocks leading to electrical reconnection. We assessed the accuracy of late gadolinium-enhanced (LGE) CMR in predicting, characterizing and localizing PV reconnection.
LGE CMR was performed 3 months after PVI in 24 patients with paroxysmal AF (age 62 ± 9 years, 4 women). Imaging was performed 15 min after contrast in transaxial and sagital orientations using an inversion-recovery prepared and respiratory navigated 3D turboFLASH sequence with fat saturation (pixel size 1.25 × 1.25 × 2.5 mm). Scar burden (mL) was quantified on transaxial images using adaptive thresholding, with a threshold set 3SD above mean blood pool signal. In addition, scar circumferentiality was assessed visually by 2 observers in consensus, potential gaps being distributed on 4 sectors per vein (sup, ant, inf, post). 1 to 3 days after CMR, all patients underwent a systematic electrophysiological study, regardless of potential AF recurrence, in order to assess for PV reconnection. Each reconnection was characterized by high density activation mapping and distributed on the same sectors.
During the index procedure, complete isolation resistant to adenosine was successfully obtained on all 4 veins in all patients. At 3 months, PV reconnection was detected in 17/24(71%) patients, with a mean extent of 1.3 ± 1.0 veins and 1.8 ± 1.6 sectors per patient. Scar burden on CMR was 10.4 ± 4.5 mL (range 3.8 to 21.3), and scar gaps were present in 16/24(67%) patients. Global analysis demonstrated a strong relationship between scar burden and PV reconnection: using an optimal cut-off of 11 mL, scar burden predicted PV reconnection with a sensitivity/specificity of 82/100%, and an inverse relationship was found between scar burden and the extent of PV reconnection (R=-0.69, p < 0.001). In contrast, on regional analysis the relationship between scar gaps and PV reconnection was limited: on a vein-by-vein basis, scar gaps on CMR predicted PV reconnection with a sensitivity/specificity of 67/92%, and on a sector-by-sector basis the agreement between scar gaps on CMR and PV reconnection was only fair (k=0.47, p < 0.001).
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.