Volume 18 Supplement 1
CMRI morphological and functional changes of the heart in myocarditis and dilated cardiomyopathy in acute pediatric heart failure
- Ahmed E Kharabish1
© Kharabish 2016
Published: 27 January 2016
Our purpose is to find morphological and functional changes of the heart in acute heart failure presentation using cardiac magnetic resonance (CMRI) in pediatric group in order to differentiate between dilated cardiomyopathy (DCM) and myocarditis as a cause of acute heart failure.
Twenty patients presented with acute heart failure. Echo and cardiac markers (including Troponin, CK, CK-MB) were performed for every patient. Patient's age ranged from 2 mo-14years. All patients underwent CMRI study. All CMRI studies were scanned using the routine protocol to fulfill the Lake Louise criteria. The performed sequences include: 1.cine stead state free precession in axial and short axis to calculate cardiac function and volumes, 2.T2 TSE in short axis cuts for cardiac edema, the cut off value of >2.3 obtained from the ratio between myocardial muscle to skeletal muscle signals was used, 3. Short axis T1 TSE before and 5 minutes after contrast injection was used as marker of capillary leakage, and delayed myocardial enhancement (LGE) in short axis and four chamber images to show the LGE pattern. Children under 6 years were sedated with chloral hydrate.
The echo and CMRI showed in all patients hypokinetic left ventricle (LV) with dilated indexed end diastolic volume (EDVI). Echo reports were positive to myocarditis in 4 patients. Cardiac markers were high in 8 patients. In patients with negative CMRI-Lake Louise criteria (12 patients) and negative cardiac markers; the average LVEDVI amounted to 159ml/m² and the average of LV ejection fraction amounted to 22%. In patients with positive CMRI lake Louise criteria (8 patients) the average LVEDVI amounted to 132ml/m² and the average of LV ejection fraction amounted to 22%. LGE in the positive cases of myocarditis was extensive and diffuse. The lateral wall was involved in all positive myocarditis patients. No LGE, edema or evidence of capillary leakage was found in DCM patients.
LV end diastolic volumes were higher in DCM patients who had negative Lake Louise criteria and negative labs markers than in positive myocarditis patients. EF% may be similar during the acute phase in both types of patients whether positive or negative to myocarditis. A prospective CMRI study will be designed to follow the changes of the EF and DE-CMRI of the same patients.
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