AML and PML in HCM group were longest among the three groups (AML: HCM 26.49 ± 4.28 vs. non HCM LVH 21.98 ± 3.57 VS. normal 21.10 ± 3.12, p < 0.001; PML: HCM 13.57 ± 3.12 vs. non HCM LVH 11.47 ± 2.35 vs. normal 11.72 ± 2.89, p < 0.001). Furthermore, AML and PML were elongating only in HCM regardless of division by LVMT(<15 mm and ≥15 mm) or hypertrophic pattern (symmetric and asymmetric) (p < 0.05). Multiple logistic regression analysis showed AML, PML and LVMT were predictors to differentiate HCM from non HCM LVH with LVMT≥15 mm (p < 0.05). When performed ROC, LVMT>21 mm was proved an optimal cutoff value to differentiate HCM from non HCM LVH with LVMT≥15 mm (AUC 0.779 [95%CI 0.708-0.839]; sensitivity 61.6%, specificity 85.71%). In patients with LVMT between 15 mm and 21 mm, AML> 24 mm and PML>13 mm showed similarly favorable differential diagnosis value between HCM and non HCM LVH by ROC curves (AML: AUC 0.761 [95%CI 0.660-0.844], sensitivity 67.4%, specificity 81.2%; PML: AUC 0.737 [95%CI 0.634-0.823]; sensitivity 51.2%, specificity 89.6%).