Volume 18 Supplement 1

19th Annual SCMR Scientific Sessions

Open Access

Cardiovascular magnetic resonance imaging of cardiac remodeling and strain analysis in adolescent obesity

  • Anna Schmidt1,
  • Alessandro Satriano1,
  • Kate Fenwick1,
  • Madeline Arnold1,
  • Andrew G Howarth1, 3,
  • Nowell M Fine3,
  • Daniele Pacaud2,
  • Todd Anderson3,
  • Bobby Heydari1, 3,
  • James A White1, 3 and
  • Matthias G Friedrich4
Journal of Cardiovascular Magnetic Resonance201618(Suppl 1):P284


Published: 27 January 2016


The increasing worldwide prevalence of childhood obesity portends the development of type 2 diabetes and cardiovascular disease (CVD) in this population. Cardiovascular Magnetic Resonance (CMR) imaging provides a sensitive imaging tool that may afford early detection of structural and functional alterations secondary to obesity. This pilot study explores the potential for CMR imaging, inclusive of left ventricular (LV) volume and mass analysis, Native T1 mapping and 4D strain analysis to identify such changes related to obesity in adolescence.


Eleven subjects between 10 and 20 years were prospectively recruited from a Pediatric Weight clinic, and defined as obese if they were ≥95th percentile of weight for their age. Fourteen age and gender-matched healthy weight control subjects were also enrolled. All subjects had baseline anthropometric and laboratory measures in addition to a standardized CMR imaging protocol, inclusive of routine multi-planar cine imaging and native T1 Mapping using the shMOLLI pulse sequence. Left Ventricular (LV) volumetric analysis and T1 mapping was blindly analyzed using cvi42 (Circle Cardiovascular Inc, Calgary). 4D strain analysis was performed using GIUSEPPE in-house software.


The mean age of the obese group was 14 ± 1 years versus 14 ± 2 years in controls (p=0.572). BMI values were higher in the obese cohort (32 ± 6 and 21 ± 4 kg/m2, p < 0.0001) as was systolic blood pressure (SBP), serum lipid levels and markers of insulin resistance. LV ejection fraction was non-significantly elevated in the obese group (62.8 ± 4.7% vs 59.1 ± 5.4%, p = 0.084). A trend was seen in elevation of LV Mass index (26.1 ± 5.9 vs 21.6 ± 6.7 g/m2.7, p = 0.084) with mean segmental wall thickness being significantly elevated in the obese cohort (5.5 ± 0.8 vs 4.6 ± 0.8 mm, p = 0.019). BMI was positively correlated with LV Mass Index (r = 0.648, p < 0.0001), wall thickness (r = 0.708, p < 0.0001) and mass:volume ratio (r = 0.415, p = 0.039). 4D strain analysis revealed significant elevations in peak circumferential endocardial strain (-20.5 ± 2.1 vs -18.7 ± 2.0% p = 0.04) and peak longitudinal endocardial strain (-16.7 ± 1.6 vs -14.4 ± 1.9% p = 0.006) in the obese cohort, consistent with a hyper-contractile state. Circumferential epicardial strain was not significantly different between groups, however, was significantly positively correlated with systolic blood pressure (r = 0.472, p = 0.023) and LV Mass Index (r = 0.484, p = 0.019). Native T1 mapping was not significantly different between the groups (954 ± 21 vs 954 ± 31 ms, p = 0.985).


In this pilot study we identify pediatric obesity to be associated with objective elevations in LV mass, wall thickness and Mass:Volume ratio. In this "early stage" of remodeling these structural changes were not associated with elevation in native T1, a surrogate marker of tissue fibrosis. Strain analysis revealed a hyper-contractile state, likely representing a combined contribution of elevated systolic blood pressure with compensatory myocyte hypertrophy.

Authors’ Affiliations

Stephenson Cardiovascular Magnetic Resonance Imaging Centre, Libin Cardiovascular Institute
Department of Paediatrics, University of Calgary
Department of Medicine, Division of Cardiology, University of Calgary
Division of Cardiology, Department of Medicine, McGill University


© Schmidt et al. 2016

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.