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Volume 18 Supplement 1

19th Annual SCMR Scientific Sessions

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The clinical and CMR Characteristics of Hypertrophic Cardiomyopathy with Restrictive Phenotype


To investigate the MR characteristics of hypertrophic cardiomyopathy (HCM) with restrictive phenotype.


19 patients of HCM with obviously restrictive characteristics and 19 typical patients with non obstructive HCM, matched with age and gender, were retrospectively collected. The clinical features, MR morphological characteristics, and the function parameters of the two groups were compared. The paired sample test and Fisher's exact probability method were used for statistical analysis.


Patients of HCM with restrictive phenotype have more severe clinical symptoms including sustained artrial fibrillation, pericardial effusion, and worse heart function classifications compared with controls; The left and right atrium diameter were 55.79 ± 5.34 mm and 61.33 ± 11.05 mm on MR, which were significantly greater than the controls (p < 0.001); The segments with late gadolinium enhancement were 7.68 ± 2.98 in patients with restrictive phenotype, which were significantly greater than controls (5.10 ± 2.77, p = 0.008). The left ventricular end-diastolic volume index, the cardiac index, and the left heart ejection fraction of patients with restrictive phenotype were all significantly less than those of the controls.


Restrictive phenotype is a special manifestation of HCM. The MR features include mild-to-moderate left ventricular hypertrophy, huge atriums, normal or small ventriculars, pericardial effusion and a wide range of late gadalinum enhancement(LGE). These patients often have severe clinical symptoms and poor prognosis. MRI has important application value in the diagnosis of the disease.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.

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Lu, M., Wu, B., Zhang, Y. et al. The clinical and CMR Characteristics of Hypertrophic Cardiomyopathy with Restrictive Phenotype. J Cardiovasc Magn Reson 18 (Suppl 1), P293 (2016).

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