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Volume 18 Supplement 1

19th Annual SCMR Scientific Sessions

Open Access

Quantitative assessment of systolic and diastolic function in patients with systemic amyloidosis

  • Daniel Kuetting1,
  • Darius Dabir1,
  • Rami Homsi1,
  • Julian A Luetkens1,
  • Hans Schild1 and
  • Daniel K Thomas1
Journal of Cardiovascular Magnetic Resonance201618(Suppl 1):P314

Published: 27 January 2016


Cardiac Magnetic ResonanceLate Gadolinium EnhancementHealthy Control GroupLongitudinal StrainCircumferential Strain


Systemic amyloidosis is a rare multisystem disease caused by extracellular accumulation of fibrillar proteins, leading to loss of normal tissue architecture and function. In clinical routine myocardial affection is assessed by late gadolinium enhancement. The aim of this study was to investigate whether patients with systemic amyloidosis (AL), both with and without cardiac affection and a healthy control group could be differentiated based on FT based systolic and diastolic strain parameters


17 Patients with systemic AL (mean age 63. ± 11.53 years; mean LVEF 64.4 ± 9 %), 17 Patients with systemic AL and cardiac magnetic resonance (CMR) late gadolinium confirmed cardiac affection (mean age 66.5 ± 12.6 years; mean EF 52.6 ± 11 %) and 10 healthy subjects (mean age 60 ± 8.9; mean EF 60.4 ± 9.2%) %), were scanned in supine position on a clinical 1.5 T MRI scanner (Philips Ingenia. Short axis slices as well as horizontal long axis views were acquired using standard SSFP-sequences. Standard CMR parameters as well as FT derived systolic and diastolic circumferential and longitudinal strain parameters were measured.


In AL patients with cardiac affection peak systolic longitudinal strain (-13.4 ± 1.9% vs 19.9 ± 1.8% ; p < 0.05), as well as the early diastolic strain rate (EDSR) (63.69 ± 18.3% vs 75.2 ± 11.9 %, p < 0,05) were significantly reduced compared to AL patients lacking cardiac affection. Peak systolic longitudinal strain in AL patients with cardiac affection was significantly reduced in comparison to the healthy control group (20.3116 ± 1.8 p < 0.0001). Both AL patients with and without cardiac affection show significantly reduced EDSR in comparison to the healthy control group (87.14 ± 16.6; p = 0.0028 and p = 0.03). A positive correlation between IVSD and longitudinal strain (r = 0.71) was found.

Peak diastolic strain rate derived from longitudinal strain (AL cardiac: 1.17 ± 0.4 vs. AL non cardiac: 1.2 ± 0.4 vs. control: 1.3716 ± 0.4), peak systolic strain rate derived from longitudinal strain (AL cardiac: -1.06 ± 0.42 vs. AL non cardiac: -1.13 ± 0.26 vs. control: -1,3366 ± 0.1) mean circumferential strain (AL cardiac: -20.4 ± 5.8 % vs. AL non cardiac: -23.8 ± 4.5% vs. control -23.2086 ± 2.3378) and peak diastolic strain derived from circumferential strain( AL cardiac: -1.24 ± 0.3 vs. AL non cardiac: 1.4 ± 0.4 vs. control: 1.3 ± 0.8) did not differ significantly between the investigated groups.


Both AL patients with and without cardiac affection showed decreased longitudinal strain and EDSR in comparison to a healthy control group, while systolic function was preserved.

Authors’ Affiliations

Radiology, University of Bonn, Bonn, Germany


© Kuetting et al. 2016

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.