- Poster presentation
- Open Access
Diagnostic accuracy of non-contrast magnetic resonance angiogram of infra-popliteal arteries prior to fibular-free flap harvest
© Elliott et al. 2016
- Published: 27 January 2016
- Peripheral Vascular Disease
- Free Flap
- Significant Disease
- Native Space
- Flap Surgery
Patients who are being evaluated to undergo fibula free flap transfer often do not have arterial disease. However a significant anatomical variant cannot be clinically excluded. Contrast enhanced magnetic resonance angiogram (CE-MRA) is commonly performed to identify the suitable side to harvest the flap and to exclude unsuitable infra-popliteal arterial anatomy. The aim of this study is to measure the quality and accuracy of a non-contrast MRA (NC-MRA) technique (Native SPACE = Non-contrast Angiography of the Arteries and Veins using Sampling Perfection with Application Optimized Contrast by using different flip angle Evolution) compared to CE-MRA.
Institutional review board approval was obtained for this study. Between October 2012 and August 2014, 16 patients underwent NC-MRA followed by CE-MRA to identify infra-popliteal arterial anatomy prior to fibular-free flap surgery. Clinically, none had symptoms of peripheral vascular disease. CE-MRA was performed in early and later arterial phases. After acquisition of one NC-MRA, it was repeated with different trigger delay at the discretion of the technologist to improve the quality. In this study, NC- and CE-MRA were randomly reviewed and their qualities were recorded on a 3- point scale for each leg: optimal (arteries and any significant disease are clearly detectable), suboptimal (arteries are detectable; however any significant disease cannot be excluded) and non-diagnostic (arteries are not detectable). Using CE-MRA as gold standard, sensitivity, specificity, positive and negative predictive values of NC-MRA in identifying the type of infra-popliteal arterial anatomy and significant disease (occlusion or >50% stenosis) was calculated.
Compared to 2-phase CE-MRA, an average 1.94 (SD 0.97) number of NC-MRA acquisitions were performed per patient. CE-MRA was optimal in all the legs (n = 32) and NC-MRA was optimal in 75%. NC-MRA was suboptimal in 19% and non-diagnostic in 6%. NC-MRA correctly identified normal and variant anatomy in 100% of optimal and suboptimal groups. Among the optimal quality NC-MRA (12 patients/69 infra-popliteal arteries), 58% demonstrated no significant disease. Compared with CE-MRA, the sensitivity, specificity, positive and negative predictive values of NC-MRA in identifying significant disease was 100%, 89%, 30% and 100% respectively.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.