Volume 18 Supplement 1
Evaluation of the diagnostic performance of self-navigated whole-heart contrast-enhanced coronary MRA at 3T
© He et al. 2016
Published: 27 January 2016
Recently, a self-navigated whole-heart coronary MRA technique has been developed to address these limitations of conventional coronary MRA techniques. Our study was to evaluate the diagnostic performance of self-navigated whole-heart coronary magnetic resonance angiography (CMRA) at 3T, using conventional invasive coronary angiography (ICA) as the reference.
60 consecutive patients underwent CMRA, 39 of which later underwent ICA. CMRA was performed on a 3T clinical scanner during free-breathing using an ECG-gated, fat-saturated, inversion-recovery prepared spoiled gradient-echo sequence with 3D radial k-space trajectory, self-navigated motion correction, and offline non-Cartesian sensitivity encoding reconstruction. The CMRA images were evaluated by two experienced readers to detect significant luminal narrowing (>50% diameter reduction).
All patients completed CMRA successfully, with one excluded from analysis (1.6%, due to poor image quality). From the 59 included patients, a total of 506 coronary segments were evaluated. In addition, 39 of the 59 patients underwent ICA, where 315 of 367 (85.8%) segments with a reference luminal diameter ≥1.5 mm were assessable on CMRA. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy on a per-patient basis were 81.8%, 81.3%, 85.7%, 76.5%, and 81.6%, respectively.
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.