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Journal of Cardiovascular Magnetic Resonance

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Volume 18 Supplement 1

19th Annual SCMR Scientific Sessions

Open Access

Quantitative assessment of left ventricular mechanical dyssynchrony using cine cardiovascular magnetic resonance imaging: inter-study reproducibility

  • Johannes T Kowallick1, 2,
  • Geraint Morton3,
  • Pablo Lamata2,
  • Roy Jogiya2,
  • Shelby Kutty4,
  • Gerd Hasenfuss5,
  • Joachim Lotz1,
  • Amedeo Chiribiri2,
  • Eike Nagel2, 6 and
  • Andreas Schuster2, 5
Journal of Cardiovascular Magnetic Resonance201618(Suppl 1):P40

Published: 27 January 2016


We aimed to determine the inter-study reproducibility of left ventricular (LV) mechanical dyssynchrony measures based on standard cardiovascular magnetic resonance (CMR) cine images.


Steady state free precession (SSFP) LV short-axis stacks as well as 2-, 3- and 4-chamber views were acquired on the same day at 9:00 (Exam A), 9:30 (Exam B) and 14:00 (Exam C) in 16 healthy volunteers. Circumferential strain systolic dyssynchrony indexes (SDI), area SDI as well as circumferential and radial uniformity ratio estimates (CURE and RURE, respectively) were derived from CMR myocardial feature tracking (CMR-FT) based on the tracking of 3 short-axis planes (basal, mid-ventricular and apical). Furthermore, 4D LV-Analysis based on short-axis stacks and all three longitudinal planes was performed to quantify 4D volume SDI. Exam A and B were compared to assess the inter-study reproducibility. Morning and afternoon scans were compared to study possible diurnal variation.


CMR-FT derived CURE and RURE as well as 4D LV-Analysis derived volume SDI showed good inter-study reproducibility (coefficient of variation [CoV] 6.4% to 12.9%, intraclass correlation coefficient [ICC] 0.79 to 0.85). Conversely, circumferential strain and area SDI showed higher variability between the repeated measurements (CoV 24.9% to 37.5, ICC 0.67 to 0.76). Averaged CURE and RURE indexes (CURE:RUREAVG) showed the lowest inter-study variation (CoV 6.4%) with an ICC of 0.80. Dyssynchrony indexes were not measurably affected by diurnal variation between morning and afternoon scans.


Derivation of LV mechanical dyssynchrony measures from standard cine images is feasible using CMR-FT and 4D LV-Analysis tools. CURE:RUREAVG and 4D volume SDI showed good inter-study reproducibility. Their clinical value should next be explored in patient groups who potentially benefit from cardiac resynchronization therapy.

Authors’ Affiliations

Institute for Diagnostic and Interventional Radiology, Georg-August University Goettingen
Division of Imaging Sciences and Biomedical Engineering, The Rayne Institute, St Thomas' Hospital, King's College London
Portsmouth Hospitals NHS Trust
Children's Hospital and Medical Center, University of Nebraska College of Medicine
Department of Cardiology and Pneumology, Georg-August-University Goettingen
Division of Cardiovascular Imaging, Goethe University Frankfurt and German Centre for Cardiovascular Research (DZHK, partner site Rhine-Main)


© Kowallick et al. 2016

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.