- Poster presentation
- Open Access
Biomarker validation of cardiac magnetic resonance analysis of regional myocardial fibrosis in ischaemic heart disease
© Costello et al. 2016
- Published: 27 January 2016
- Cardiac Magnetic Resonance
- Late Gadolinium Enhancement
- Myocardial Fibrosis
- Automate Threshold
- Segment Elevation Myocardial Infarction
Late gadolinium enhancement (LGE) with CMR is commonly assumed to represent myocardial fibrosis; however, comparative human histological data are limited, and there is no consensus on the most accurate method for LGE quantitation. We evaluated the relationship between CMR assessment of regional fibrosis and infarct size assessment using serial biomarkers after ST segment elevation myocardial infarction (STEMI).
Ninety-five patients treated for STEMI (59 ± 10 years, 85% male) underwent CMR six months after infarction. Fibrosis was quantified by CMR-LGE using visual and automated thresholds, and compared with the rise in serum biomarkers.
Quantification methods had a strong influence on the infarct size assessment with CMR-LGE. Significant correlations were observed between LGE and biomarkers across a range of signal intensity thresholds (range: 2-10 standard deviations [SD] above reference myocardium), however there was a wide range with respect to estimation of total LGE size (from 6.8 ± 7.7 to 32.1 ± 11.3 grams) and a smaller variation in the correlation with peak troponin level (R-values ranging from 0.715 to 0.834). The strongest correlation was observed at thresholds of 5 and 6 SD (R = 0.830, P < 0.001 and R = 0.834, P < 0.001).
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