Figure 2

(A) Native myocardial T1 values increase and return to baseline after iv injection of LNAME and ET-1. At the peak of the response (14 minutes), the injection of LNAME and ET-1 caused an average of 92 ms increase in native myocardial T1 (*p < 0.05 vs.baseline). (B) Without pharmacological agents, the partition coefficient of gadolinium-labeled albumin was 0.21 ± 0.017 and it increased to 0.27 ± 0.013 after administering LNAME and ET-1 (*p < 0.05 vs. control). All data shown are mean ± standard error.