Multiparametric cardiovascular magnetic resonance surveillance of acute cardiac allograft rejection and characterisation of transplantation-associated myocardial injury: a pilot study

Table 4 Selected CMR parameters displayed according to the presence of primary graft dysfunction (PGD)

	Scan 1 (6.9 weeks)	Scan 2 (10.9 weeks)	Scan 3 (16.6 weeks)	Scan 4 (22.3 weeks)	p value
LVEDVI (mL/m²)
No PGD	78.5 ± 14.6	76.4 ± 15.5	77.4 ± 16.5	77.7 ± 14.1
PGD	127.5 ± 16.6^†	127.3 ± 12.1^†	123.7 ± 10.4^†	123.6 ± 12.8^†	<0.001
LVESVI (mL/m²)
No PGD	29.1 ± 8.3	27.3 ± 8.9	27.0 ± 9.5	27.9 ± 9.2
PGD	94.2 ± 7.5^†	89.4 ± 11.1^†	81.7 ± 5.8^†	81.4 ± 17.9^†	<0.001
LVEF (%)
No PGD	63.0 ± 7.5	64.8 ± 7.7	65.4 ± 8.7	64.5 ± 7.9
PGD	26.2 ± 4.9^†	29.9 ± 2.2^†	33.7 ± 5.8^†	34.5 ± 7.8^†	<0.001
εcc (%)
No PGD	−13.1 ± 3.6	−14.0 ± 2.6	−15.0 ± 3.5	−14.9 ± 2.9
PGD	−8.5 ± 3.3*	−9.3 ± 1.7*	−9.3 ± 1.6*	−10.9 ± 0.6	<0.001
Native T₁ (ms)
No PGD	1099 ± 42	1067 ± 42	1066 ± 59	1055 ± 32
PGD	1167 ± 79*	1184 ± 66^†	1177 ± 50^†	1122 ± 66*	0.001
T₂ (ms)
No PGD	58.0 ± 2.88	56.6 ± 3.2	56.2 ± 2.7	55.3 ± 2.3
PGD	64.7 ± 0.93^†	60.5 ± 3.4	60.3 ± 0.5*	60.8 ± 3.0^†	<0.001

p values refer to the significance of the difference in each CMR parameter between the presence and absence of PGD taking into account all time points, assessed using generalized estimating equations. The significance of the difference in each CMR parameter between the presence and absence of PGD at each individual time point, assessed using independent t tests, is denoted by *(p < 0.05) or ^†(p < 0.01). Abbreviations as per Table 2.

ISSN: 1532-429X