Flow chart of the atlas construction. (a) Fiducial landmarks defined at ED on short and long axis images (3D view from anterior). Red markers denote the mitral valve and purple markers denote the intersections of the right ventricular free wall and the septum. The base plane is drawn as a yellow disc. (b) Contours drawn on short axis slices by the core lab. Individual breath-holds for each 2D slice result in mis-alignment between slices. (c) 3D finite element model showing epicardial control points (model shape parameters) and element boundaries. (d) Breath-hold mis-registration correction by alignment to the model. (e) Principal component analysis of atlas shape variation. Upper and lower panels show ±2 standard deviations in the principal component shape.