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Table 1 Summary of quantitative results for diffusion biomarkers and local myocyte orientation

From: A high-resolution cardiovascular magnetic resonance diffusion tensor map from ex-vivo C57BL/6 murine hearts

Parameter (Non-normalized/normalized)

HA Range (°)

FA

MD (x10−3 mm2/s)[Non-Normalized]MD (mm2/s) [Normalized]

Region

Epi

Epi-Mid

Mid

Mid-Endo

Endo

Epi

Epi-Mid

Mid

Mid-Endo

Endo

Epi

Epi-Mid

Mid

Mid-Endo

Endo

Apex

Septal

19 ± 8

31 ± 2

37 ± 2

39 ± 1

26 ± 9

0.234/0.019

0.251/0.020

0.260/0.021

0.244/0.020

0.210/0.017

0.862/0.998

0.843/0.989

0.829/0.982

0.836/0.990

0.845/0.993

Inferior

−10 ± 3

2 ± 8

25 ± 7

41 ± 4

44 ± 3

0.307/0.026

0.312/0.026

0.275/0.022

0.240/0.020

0.224/0.018

0.812/0.980

0.807/0.976

0.829/0.981

0.837/0.977

0.862/0.984

Lateral

−50 ± 8

−32 ± 4

−13 ± 8

18 ± 8

40 ± 7

0.225/0.018

0.241/0.019

0.235/0.019

0.251/0.020

0.241/0.019

0.835/0.995

0.810/0.980

0.837/0.982

0.876/0.992

0.935/1.033

Anterior

−18 ± 12

−20 ± 3

−8 ± 4

7 ± 6

27 ± 6

0.224/0.019

0.303/0.025

0.269/0.021

0.251/0.020

0.241/0.019

0.992/1.016

0.866/0.992

0.887/0.996

0.901/0.993

0.918/1.002

Mid

Septal

−39 ± 5

−11 ± 15

25 ± 5

42 ± 4

52 ± 5

0.210/0.017

0.226/0.018

0.261/0.021

0.269/0.022

0.227/0.018

0.868/0.990

0.832/0.982

0.800/0.977

0.816/0.989

0.859/1.000

Inferior

−37 ± 7

−14 ± 7

9 ± 9

34 ± 7

52 ± 5

0.308/0.025

0.347/0.029

0.312/0.026

0.258/0.021

0.228/0.019

0.805/1.026

0.783/0.989

0.807/0.982

0.823/0.977

0.832/0.981

Lateral

−41 ± 3

−24 ± 5

−3 ± 8

23 ± 8

39 ± 6

0.266/0.022

0.294/0.025

0.255/0.021

0.221/0.019

0.204/0.016

0.845/1.020

0.790/0.983

0.812/0.978

0.832/0.989

0.908/1.049

Anterior

−28 ± 4

−23 ± 3

−11 ± 5

7 ± 6

28 ± 8

0.266/0.021

0.322/0.026

0.296/0.024

0.281/0.022

0.249/0.020

0.932/1.022

0.853/0.987

0.850/0.984

0.843/1.000

0.883/1.013

Base

Septal

−47 ± 2

−25 ± 13

13 ± 11

37 ± 5

54 ± 5

0.227/0.018

0.231/0.019

0.250/0.020

0.275/0.023

0.243/0.020

0.851/0.987

0.807/0.977

0.768/0.973

0.757/0.969

0.779/0.972

Inferior

−43 ± 7

−25 ± 6

−7 ± 6

15 ± 8

41 ± 8

0.304/0.025

0.368/0.031

0.342/0.028

0.269/0.022

0.227/0.019

0.820/1.030

0.766/0.995

0.804/0.989

0.828/0.977

0.848/0.990

Lateral

−49 ± 3

−40 ± 3

−22 ± 8

−3 ± 5

15 ± 5

0.323/0.028

0.310/0.026

0.236/0.020

0.214/0.018

0.212/0.017

0.804/0.999

0.804/0.986

0.813/0.978

0.822/0.981

0.840/0.992

Anterior

−20 ± 6

−30 ± 2

−28 ± 2

−19 ± 5

−5 ± 5

0.251/0.020

0.306/0.026

0.273/0.022

0.243/0.020

0.204/0.017

0.934/1.075

0.821/0.990

0.803/0.975

0.801/0.984

0.833/1.017

Globally averaged value *

111 ± 23

[n = 5, C57BL/6;b = 1850]

(This study)

0.25 ± 0.07 (This study)

0.89 ± 0.16 (This study) [Non-normalized]

126 ± 3*

[n = 10, 129/ola]

(Healy 2011)

0.27 ± 0.06 [33]

0.75 ± 0.13 [33]

143 ± 12*

[n = 2, 129/ola;b = 1130]

[33]

0.38 ± 0.16 [55]

0.7 ± 0.25 [55]

110

[n = 14,C57B16/J]

[49]

125[55]

[n = 4, Swiss;b = 1440]

[55]

  1. Sectorial (non-normalized normalized) and globally-averaged quantitative comparison of DTI-based parameters (HA, FA, MD) from the constructed mean tensor map and based on fixed murine hearts and the PPD re-orientation/registrations strategies.
  2. *Transmurally-averaged values (epicardium to endocardium) from the entire LV myocardium (including anterior, lateral, inferior and septal areas).
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Journal of Cardiovascular Magnetic Resonance

ISSN: 1532-429X

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