Table 1 Baseline clinical characteristics of severe AS patients and normal controls

Age (years)

67.8 ± 9

63.3 ± 3.4

0.06

Male, n (%)

19 (73)

8 (53)

0.16

Past medical history, n (%)

Hypertension

10 (38)

-

Diabetes

4 (15)

-

Medications, n (%)

Metformin

4 (15)

-

ACE-I/ARB-II

7 (27)

-

Beta-blockers

5 (19)

-

Body mass index (kg/m²)

27.8 ± 4.5

27.0 ± 3.8

0.38

Systolic blood pressure (mmHg)

134.4 ± 18.1

131.0 ± 11.0

0.51

Diastolic blood pressure (mmHg)

74.4 ± 9.4

76.5 ± 10.2

0.51

Heart rate (bpm)

66.1 ± 9.4

64.3 ± 10.5

0.58

Peak AV gradient (mmHg)*

83.1 ± 14.6

-

CMR findings

Aortic valve area (cm²)

0.82 ± 0.02

4.04 ± 0.75

<0.001

LV end-diastolic volume (ml)

143.2 ± 44.4

133.7 ± 33.1

0.47

LV ejection fraction (%)

74.5 ± 5.8

68.8 ± 6.4

0.005

LV mass index (g/m²)

96.0 ± 31.2

55.8 ± 13.9

<0.001

Presence of LGE, n (%)

21 (81)

0

<0.001

Myocardial T1 (ms)

1196 ± 47

1168 ± 27

0.037