Fig. 4
From: The diagnostic value of iron oxide nanoparticles for imaging of myocardial inflammation – quo vadis?
Comparison between SPIO-CMR and LGE-CMR. T1-weighted LGE-CMR before (a) and after (b) gadolinium injection, and T2*-weighted SPIO-CMR before (d) and after (e) SPIO injection in the same EAM rats are compared. Whereas weakly enhanced areas (b, white arrowheads) are visualized in the left ventricular wall in the LGE-CMR, the positively enhanced area becomes negative contrasted (e, white arrowheads) in SPIO-CMR. Magneto-fluorescent nanoparticle CMR provides more specific identification of inflammatory lesions (e, yellow arrows) than LGE-CMR and more pronounced changes in CNR (c and f). The negative contrast regions in the SPIO-CMR are in good agreement with inflamed areas in H&E images (g), macrophage infiltrations in IHC images (h), and SPIO-fluorescence spots in FM (i). CNR: contrast-to-noise ratio; H&E: haematoxylin and eosin; IHC: immunohistochemistry; FM: fluorescence microscopy. Reproduced with permission from Moon et al. [54]