Fig. 3

Results from Monte Carlo simulations of the TwiST experiment (without spill-over correction) over a range of TR_long (with γ-ATP saturated) and TR_control (control saturation), averaged over a range of k_f from 0.1-0.4 s⁻¹ and T₁ ^intrinsic from 5–9 s. Averages were chosen for a constant total study time of 30 min. a The relative percentage SD in k_f for average choices that led to the smallest error at each TR combination. b The average bias error in k_f, corresponding to the same TR and average combinations as in a) and T₁ ^intrinsic of 7 s. The red dot illustrates the TRs used in the human acquisitions in this study (TR_long = 10s and TR_control = 16 s)