Fig. 3

Apical hypertrophy in Anderson-Fabry Disease (AFD). Short-axis (a-c) and 2-chamber (d) cine steady state free precession and short-axis (e-g) and 2-chamber (h) late gadolinium enhancement images in a patient with Anderson-Fabry Disease on enzyme replacement therapy and a history of non-sustained ventricular tachycardia. Cardiovascular magnetic resonance revealed an apical pattern of hypertrophy (lack of apical tapering in end-diastole [white curved arrows on image D]) and obvious intermediate intensity midwall and subendocardial apical scar (white arrows on images g, h. This is not typical of ischemic heart disease - lack of high intensity myocardial scar and preserved muscle bulk. There is also subtle intermediate intensity subepicardial scar in the mid inferolateral segment (white arrowheads on image f. There was more scar in the apical LV than the mid and basal LV (Basal LV scar 10 %; Mid LV scar 9 %; Apical LV scar 38 %)